Brea C. Lipe, MD describes the unique treatment technology explored in the PERSEUS phase three trial.
Summary
This segment focuses on a large, 700+ patient randomized phase three trial conducted by the European Myeloma Network comparing a quadruplet drug regimen (lenalidomide, bortezomib, dexamethasone, and subcutaneous daratumumab) to a triplet regimen without daratumumab for multiple myeloma. The quadruplet regimen demonstrated improved progression-free and overall survival compared to the triplet. The use of subcutaneous daratumumab makes the regimen more convenient for patients than prior intravenous regimens. While efficacy and safety are most important, convenience is a consideration for many patients in terms of quality of life and logistics. This trial provides evidence that this quadruplet regimen is effective and more convenient for patients.
Summary was AI-generated and edited for clarity.
Landgren on MRD as an End Point for Multiple Myeloma Trials
May 1st 2024C. Ola Landgren, MD, PhD, discussed the FDA’s unanimous ODAC vote supporting minimal residual disease as an accelerated approval end point in multiple myeloma and the implications of this vote in the myeloma research field.
Read More
Age, Disease Burden Are Factors in Early Use of Selinexor in Multiple Myeloma
April 22nd 2024During a Case-Based Roundtable® event, Jonathan L. Kaufman, MD, discussed treatment approaches and the tolerability of a selinexor-containing regimen in a patient with relapsed/refractory multiple myeloma in the first article of a 2-part series.
Read More