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Opinion|Videos|March 20, 2025

Academic Perspectives on Systemic Therapy for Advanced uHCC

Author(s)Amit Mahipal, MD

An expert discusses how, for advanced unresectable hepatocellular carcinoma (uHCC), clinicians monitor treatment efficacy through imaging, α-fetoprotein levels, and tolerability. Treatment decisions are guided by response assessment, adverse events, and liver function. First-line (1L) options include tyrosine kinase inhibitors and immunotherapy combinations, with promising trials exploring novel immune combinations and targeted approaches that may reshape the treatment landscape.

Episodes in this series

1 expert in this video

EP. 1 A 57-Year-Old Woman Diagnosed with Advanced Unresectable Hepatocellular Carcinoma

1 expert in this video

EP. 2 Recent Advances in Front-Line Systemic Therapy for Advanced uHCC

1 expert in this video

EP. 3 Clinical Insights and Patient Considerations for Frontline TKI Therapy in Advanced uHCC

1 expert in this video

EP. 4 Lenvatinib and Depth of Response in Advanced uHCC: Insights From REFLECT

1 expert in this video

EP. 5 Optimizing Frontline TKI Therapy in Advanced uHCC: Managing Adverse Events

1 expert in this video

EP. 6 Academic Perspectives on Systemic Therapy for Advanced uHCC

Video content above is prompted by the following:

What remaining clinical pearls can you share regarding systemic therapy treatment approaches for patients with advanced uHCC?
How do you evaluate treatment success over time, and what are key indicators that guide decisions regarding treatment modifications or sequencing?
What trials are you anticipating that might affect the 1L treatment of uHCC?

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