Case 3: Front Line Therapy Options in ET

EP: 1.Case 1: Hydroxyurea-Resistant Polycythemia Vera (P. Vera)

EP: 2.Case 1: Diagnosis of P. Vera

EP: 3.Case 1: Risk Assessment in P. Vera

EP: 4.Case 1: Initial Treatment Options for Low Risk P. Vera

EP: 5.Case 1: Considerations for Cytoreductive Therapy in P. Vera

EP: 6.Case 1: Treatment Options after Hydroxyurea Failure in P. Vera

EP: 7.Case 1: Treatment Approaches for High Risk P. Vera

EP: 8.Case 1: Role of Symptomatic Improvement in Overall Outcome in MF

EP: 9.Case 2: High Risk Myelofibrosis (MF)

EP: 10.Case 2: Prognostic Models of MF

EP: 11.Case 2: Predictors of Response to Ruxolitinib in High Risk MF

EP: 12.Case 2: Safety and Efficacy of Ruxolitinib in High Risk MF

EP: 13.Case 2: Efficacy and Safety of Fedratinib in High Risk MF

EP: 14.Case 2: Considerations for Optimizing Therapy in High Risk MF

EP: 15.Case 3: Essential Thrombocythemia (ET)

EP: 16.Case 3: Risk Assessment in ET

EP: 17.Case 3: Individualized Therapy for ET

EP: 18.Case 3: Molecular Profile and Initiation of Therapy in ET

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EP: 19.Case 3: Front Line Therapy Options in ET

EP: 20.Case 3: Disease Progression and Transformation in ET

Ruben Mesa, MD: Prithviraj, the guidelines offer 3 options as frontline therapy. As I like to say, there’s both the art and the science of medicine. The guidelines help provide the science. The art is which of the medicines you choose. How do you choose between those frontline options in ET?

Prithviraj Bose, MD: Hydroxyurea, pegylated interferon, and maybe even anagrelide could be considered frontline options. However, I do not use anagrelide as a frontline option. I keep it to hydroxyurea and interferon. My view thus far with interferon has been that I tend to offer it if the patient is very young, younger than 40, or if pregnancy is a consideration. Otherwise, I tend to default to Hydrea. As this panel is well aware, the leukemogenicity has never been proven. It sometimes comes up and tends to be an area of some controversy, but since it has never been proven and it is an effective, inexpensive, convenient, and safe drug, I usually go with hydroxyurea.

This transcript has been edited for clarity.