May 9th 2024
During a Case-Based Roundtable® event, Madappa Kundranda, MD, PhD, discussed recent retrospective studies that looked at outcomes of dose optimization of regorafenib for patients with relapsed/refractory advanced colorectal cancer in the first article of a 2-part series.
Community Practice Connections™: Real-World Applications of Novel Therapies Across TNBC and Addressing Disparities in Care
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6th Annual Precision Medicine Symposium: An Illustrated Tumor Board
October 18-19, 2024
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Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
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Significant Benefit Seen With BRAF/MEK/EGFR Triplet Regimen in mCRC
July 9th 2019Updated results from an interim analysis of the phase III BEACON CRC trial demonstrated a significant improvement in overall survival for the triplet regimen of encorafenib, binimetinib, and cetuximab compared with cetuximab and irinotecan-containing regimens in patients with previously treated <em>BRAF </em>V600E–mutant metastatic colorectal cancer.
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Regorafenib Plus Nivolumab Limits Tumor Growth In Gastric and Colorectal Cancers
July 2nd 2019In an interview with <em>Targeted Oncology</em>, Shota Fukuoka, MD, PhD, of the Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan, commented on the results of the study and the future plans to expand the research with a larger cohort.
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FDA Approves Bevacizumab Biosimilar Zirabev
June 28th 2019The FDA has approved Zirabev, a biosimilar to bevacizumab for 5 indications. Zirabev has been approved for the treatment of patients with metastatic colorectal cancer; unresectable, locally advanced, recurrent or metastatic non-squamous non–small cell lung cancer; recurrent glioblastoma; metastatic renal cell carcinoma; and persistent, recurrent or metastatic cervical cancer.
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Triplet Regimen Improves Responses in BRAF V600E+ Metastatic CRC
June 24th 2019Tanios Bekaii-Saab, MD, discusses the results from the phase III BEACON CRC study; investigators evaluated the efficacy and safety of triplet encorafenib, binimetinib, and cetuximab in patients with BRAF V600E–mutant metastatic colorectal cancer who previously received up to 2 lines of prior therapy.
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Treatment Patterns at End of Life Explored in Large, National Database
June 20th 2019The American Cancer Society, Dana-Farber Cancer Institute, Baptist Cancer Center, and the Mayo Clinic report that treatment patterns varied markedly by cancer type and care facility setting for patients with de novo metastatic disease who died within 1 month after diagnosis, based on an analysis of data from 100,848 patients collected from the National Cancer Database, a hospital-based cancer registry that captures 70% of patients in the United States with a new diagnosis.
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FDA Issues Draft Guidance to Broaden Clinical Trial Inclusion
June 19th 2019The FDA recently released 5 new draft guidance documents that promote broader patient eligibility for cancer clinical trials. The policies encourage inclusion of certain individuals who were previously disqualified due to medical conditions or biological factors, including brain metastases, organ dysfunction, prior or concurrent malignancies, chronic infections, and age.
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Bevacizumab Added to CAPIRI Shown to be Safe and Effective in Metastatic CRC
June 17th 2019When bevacizumab was added to capecitabine plus irinotecan, the combined regimen was shown to be a safe and effective second-line treatment option for patients with metastatic colorectal cancer, according to findings from a phase II trial published recently in the International Journal of Clinical Oncology.
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Strategies to Engage Underrepresented Populations Improves Inclusivity in Clinical Trials
June 17th 2019A cohort of cancer centers was selected to serve as models for identifying key strategies for racial and ethnic minority group engagement in clinical trials. On the basis of several qualifying criteria, such as sustained accrual of minorities into clinical cancer research, an established minority population ≥10% in the overall catchment, an established clinical trial infrastructure, and a formal community outreach program, the investigators identified 8 cancer centers for participation.
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Novel Combinations Explored in CRC With Rare Gene Mutations
June 15th 2019In a case-based-style discussion, Tanios S. Bekaii-Saab, MD, and Wells Messersmith, MD, reviewed the treatment of patients with colorectal cancer whose tumors express rare gene mutations or molecular signatures, such as <em>NTRK</em> fusions.
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Bekaii-Saab Considers TKI Therapy to Treat Patients With Advanced GI Cancers
June 13th 2019During a recent <em>Targeted Oncology </em>live case-based peer perspectives presentation, Tanios Bekaii-Saab, MD, discussed with a group of physicians the treatment options for patients with gastrointestinal cancers and the characteristics that influence his decision making. Bekaii-Saab explained his clinical decisions based on the case scenario of one patient with colorectal cancer and one with hepatocellular carcinoma.
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Laparoscopic Surgery Demonstrates Similar Survival Rates to Open Surgery for CRC Liver Metastases
June 3rd 2019Patients with colorectal cancer and liver metastases who underwent laparoscopic surgery had similar long-term rates of overall survival compared with patients who had open liver surgery, according to results of the randomized OSLO-COMET trial. These findings were presented in a press briefing during the 2019 ASCO Annual Meeting.
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Overall Survival, Response Rate Improved With Triplet Regimen in BRAF-Mutant CRC
May 23rd 2019The combination of encorafenib, binimetinib, and cetuximab reduced the risk of death by 48% in patients wtih <em>BRAF</em> V600E-mutant metastatic colorectal cancer who have received up to 2 prior lines of therapy compared with cetuximab and irinotecan-containing regimens, according to the phase III BEACON CRC trial, which met both its primary endpoints.
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Stimulatory Effects Observed With Vaccine in Early-Stage CRC
May 20th 2019Investigators on a first-in-human phase I trial found that antibody and T-cell responses were detected in a vaccine targeting GUCY2C, a commonly overexpressed protein in patients with early-stage colorectal cancer.<br />
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