Considering Radiation and Preoperative Therapy Options in Locally Advanced GEJ Cancers

Weijing Sun, MD, discusses a major topic in locally advanced gastroesophageal junction adenocarcinoma covered at the 2018 ISGIO Annual Conference in Arlington, Virginia.

Weijing Sun, MD, gastrointestinal oncologist at the University of Kansas School of Medicine, discusses a major topic in locally advanced gastroesophageal junction (GEJ) adenocarcinoma covered at the 2018 ISGIO Annual Conference in Arlington, Virginia.

At the conference, experts debated the role of radiation therapy in this patient population, Sun says. Two studies looked at different preoperative therapy options with encouraging data both with and without radiation.

The FLOT study explored a regimen of fluorouracil, leucovorin, oxaliplatin, and docetaxel for this patient population, without radiation. The CROSS study looked at the combination of carboplatin and paclitaxel with radiation.