MPNs

Ruxolitinib Plus Post-Transplant Cyclophosphamide Controls GVHD in Myelofibrosis

May 20, 2020

“In this study, we evaluated ruxolitinib as a bridge, relapse, and GVHD prevention agent in patients with myelofibrosis. The regimen was well tolerated, with an acceptable rate of organ toxicity."

Blast Phase Not Stalled With Ruxolitinib Treatment in Myelofibrosis, Study Shows

May 20, 2020

A new analysis of nearly 600 patients with myelofibrosis found patients who take ruxolitinib progress to blast phase at approximately the same rates as those who are ruxolitinib-naïve.

Momelotinib May Fill Treatment Gap for Anemia in Myelofibrosis

May 19, 2020

Momelotinib for the treatment of patients with myelofibrosis may address concerns with the development of cytopenias, an issue no approved therapy has been able to solve.

Steroid-Refractory Chronic GVHD Requires More Treatment Options

May 14, 2020

Corey S. Cutler, MD, MPH, discusses the current treatment options for patients with chronic graft-versus-host-disease and highlighted some upcoming research.

The Value of Prognostication in the Modern Management of Myelofibrosis

May 13, 2020

In an interview with Targeted Oncology, Verstovsek, medical oncologist and professor, Department of Leukemia, University of Texas MD Anderson Cancer Center, discussed mutational profiling for myelofibrosis and how the information obtained can be valuable for clinical management of the disease.

Investigators Study JAK Inhibitors in Patients With Myelofibrosis

May 11, 2020

Ruben Mesa, MD, discusses the role of JAK inhibitors, which are currently being investigated in patients with myelofibrosis. He also spoke to what the future of this treatment landscape may be.

Young Adult and Pediatric Patients With MPNs Should Remain Hopeful, Expert Says

April 13, 2020

In an interview with Targeted Oncology, Nicole Kucine, MD, MS, discussed the findings from her review of the literature on children, adolescents, and young adults with myeloproliferative neoplasms. She highlighted what next steps are needed in this space in terms of research and what a community oncologist should do should for younger patients with myeloproliferative neoplasms.

Anti-Cancer Agents as Frontline Treatment of MPNs Lead to Higher Probability of Non-Melanoma Skin Cancers

April 10, 2020

Exposure to ruxolitinib, hydroxyurea, and pipobroman as first-line treatment of Philadelphia-negative myeloproliferative neoplasms alone or in combination with other cytoreductive treatment may increase the probability of patients developing non-melanoma skin cancer, highlighting a need for active dermatological surveillance of these patients, according to findings from the MPN-K study, published in Leukemia.

Treating GVHD in Patients with Myelofibrosis Following Transplant

April 10, 2020

Tania Jain, MBBS, discusses the current treatment options for graft-versus-host-disease, a known complication of allogeneic stem cell transplant, which is the only curative treatment option for patients with myelofibrosis.

FDA Approves Luspatercept for Myelodysplastic Syndrome-Associated Anemia

April 04, 2020

The FDA granted approval to luspatercept-aamt as treatment of adult patients with anemia failing an erythropoiesis stimulating agent that requires 2 or more red blood cell units over 8 weeks, that is associated with very low- to intermediate-risk myelodysplastic syndromes, intermediate-risk myelodysplastic syndromes with ring sideroblasts or myelodysplastic/myeloproliferative neoplasm.