Leukemias

Analyzing CAR T-Cell Neurotoxicity in Adult Patients With ALL

May 18, 2020

Jae Park, MD, discusses adverse events associated with chimeric antigen receptor T-cell therapies, such as neurotoxicity, for patients with acute lymphocytic leukemia.

Microfluidic Platforms Help Isolate Rare Cells in Leukemias

May 17, 2020

In an interview with Targeted Oncology, Steve A. Soper, PhD, discussed microfluidic platforms for use in isolating circulating leukemia cells and plasma cells in patients with acute lymphoblastic leukemia and acute myeloid leukemia.

FDA Grants Orphan Drug Designation to HQP1351 in Chronic Myeloid Leukemia

May 04, 2020

There is a significant unmet clinical need [for] treatment of CML globally. This Orphan Drug Designation from FDA marks a major milestone for HQP1351..."

Longest Follow-Up Maintains Ibrutinib Benefit in CLL/SLL Across Treatment Settings

April 13, 2020

The longest follow-up for ibrutinib monotherapy to date maintained the benefit of the Bruton’s tyrosine kinase inhibitor for patients with chronic lymphocytic leukemia/small lymphocytic lymphoma across settings.

Frontline Treatment Options Available for Patients With CLL

April 11, 2020

Jennifer Woyach, MD, discusses the frontline options for the treatment of patients with chronic lymphocytic leukemia.

Prognostic Tool Predicts Length of Watch and Wait Period in CLL

April 10, 2020

The appropriate gap between diagnosis of chronic lymphocytic leukemia and treatment is now clearer as a new prognostic tool, IPS-E, that can predict the length of “watch and wait” has been introduced, according to a press release from the American Society of Hematology.

Evaluating Older Patients With Acute Myeloid Leukemia in SIERRA Trial

April 08, 2020

Rajneesh Nath, MD, discusses the rationale for phase III SIERRA trial, which evaluated the anti-CD45 monoclonal antibody apamistamab followed by fludarabine/total body irradiation and allogeneic hematopoietic cell transplantation in patients with relapsed/refractory acute myeloid leukemia.

Early FCR Lacks Evidence to Change Standard Watch & Wait in Stage Binet A High-Risk CLL

April 02, 2020

Although fludarabine, cyclophosphamide, and rituximab may be efficient in inducing remission for the treatment of patients with Binet A high-risk chronic lymphocytic leukemia, recent data published in Leukemia suggest there is no evidence that this would be better than the current standard of care, which is the “watch and wait” approach.

Acalabrutinib Appears Tolerable in Chronic Lymphocytic Leukemia

April 02, 2020

Jeff P. Sharman, MD, discusses the secondary end points from the phase III ELEVATE-TN trial, which evaluated the role of acalabrutinib, either as a single agent or in combination with obinutuzumab in patients with treatment-naive chronic lymphocytic leukemia.

AML Trial Halted Due to COVID-19 Pandemic

March 30, 2020

A phase II trial of ficlatuzumab, an investigational HGF inhibitory antibody, in patients with relapsed and refractory acute myeloid leukemia joins the growing list of clinical trials halted due to the coronavirus disease 2019 pandemic.