November 27th 2023
During a Targeted Oncology™ Case-Based Roundtable™ event, Devika Das, MD, discussed the role of KRAS inhibitors and the outcome of the KRYSTAL-1 trial in patients with non–small cell lung cancer. This is the first of 2 articles based on this event.
November 10th 2023
Burst CME™ - Part II – Advent of HER3 Targeted Approaches and Rationale in NSCLC Care
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Burst CME™ - Part I – Overview of Pathophysiology, Diagnosis, and Management of HER3 Expressing Cancers
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Burst CME™ - Part III – Advent of HER3 Targeted Approaches and Rationale in Breast Cancer Care
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Medical Crossfire®: Antibody-Drug Conjugates Coming to Your Oncology Practice Tomorrow
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Community Practice Connections™: 6th Annual Precision Medicine Through Plasma™ – Using Liquid Biopsies in Contemporary Oncology Care
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40th Annual CFS®: Innovative Cancer Therapy for Tomorrow®
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Community Practice Connections™: Real-World Applications of Novel Therapies Across TNBC and Addressing Disparities in Care
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Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
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42nd Annual CFS®: Innovative Cancer Therapy for Tomorrow®
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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EGFR Exon 20-Insertion NSCLC Population Sees PFS Benefit from Amivantamab/Chemotherapy
October 21st 2023Combining amivantamab, carboplatin, and pemetrexed in patients with non–small cell lung cancer and an EGFR exon 20 insertion led to improved progression-free survival, overall response rate, duration of response, and a trend toward overall survival benefit vs chemotherapy alone in the randomized phase 3 PAPILLON study.
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Managing Adverse Events in EGFR Exon 20 Insertion–Targeted Therapies for NSCLC
October 20th 2023During a Targeted Oncology™ Case-Based Roundtable™ event, Millie S. Das, MD, and participants discussed considerations for managing toxicities of amivantamab and mobocertinib for patients with EGFR exon 20 insertion–positive non–small cell lung cancer.
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Adagrasib/Pembrolizumab Promising in KRAS G12C-Mutated NSCLC
October 20th 2023Longer follow-up data from the KRYSTAL-7 trial support the initiation of a phase 3 trial evaluating concurrent adagrasib with pembrolizumab in treatment-naïve patients with KRASG12C-mutated non–small cell lung cancer and PD-L1 ≥50%.
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Randomized Trial Provides Biomarker and CNS Sotorasib Data in NSCLC
October 4th 2023During a Targeted Oncology™ Case-Based Roundtable™ event, Timothy F. Burns, MD, PhD, discussed the results of the phase 3 CodeBreaK 200 trial in patients with KRAS G12C-positive lung cancer. This is the second article based on this event.
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Identifying the Role of Targeted Therapy in KRAS-Mutated NSCLC
September 26th 2023During a Targeted Oncology™ Case-Based Roundtable™ event, Timothy F. Burns, MD, PhD, discussed the use of sotorasib and adagrasib for patients with KRAS-mutated non–small cell lung cancer including those with brain metastases.
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Bintrafusp Alfa Shows Similar Efficacy to Pembrolizumab in PD-L1-High/Advanced NSCLC
September 1st 2023No significant difference in efficacy outcomes were shown with bintrafusp alfa vs pembrolizumab in patients with PD-L1-high, advanced non–small cell lung cancer. However, further investigation may offer more information about the benefit of this drug class.
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TROPION-Lung01 Trial of Datopotamab Deruxtecan Meets PFS End Point in NSCLC
July 10th 2023Progression-free survival data from the phase 3 TROPION-Lung01 trial showed that datopotamab deruxtecan as treatment of metastatic non–small cell lung cancer crossed the threshold for statistical significance.
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Pembrolizumab Maintains Efficacy After 5 Years in First-Line, PD-L1+, Advanced NSCLC
July 1st 2023Findings from the 5-year follow-up analysis of the phase 3 KEYNOTE-042 study continue to support frontline pembrolizumab as standard of care for PD-L1-positive, locally advanced/metastatic non–small cell lung cancer.
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Rezivertinib Generates Promising CNS Efficacy in NSCLC With an EGFR T790M Mutation
June 19th 2023Individual data from 2 studies evaluating rezivertinib in patients with advanced non–small cell lung cancer harboring an EGFR T790M mutation and CNS metastases displayed encouraging efficacy and safety findings.
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Real-World Data Shows Significant Increase of Biomarker Testing in Past Decade for NSCLC
May 8th 2023Looking at real-world data, researchers identified a large increase of biomarker testing for patients with early-stage non–small cell lung cancer, which indicates a continuing trend toward personalized treatment.
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