Medicaid Grants Coverage of Blood-Based Biomarker Testing in CRC Despite Lack of an Assay

February 25, 2021

The Centers for Medicare & Medicaid Services have found that there is sufficient evidence for the coverage of blood-based biomarker tests to be granted for patients with colorectal cancer once every 3 years or at a specific individual test interval labeled by the FDA.

FDA Grants Breakthrough Therapy Designation to Tipifarnib in HRAS+ HNSCC

February 25, 2021

The FDA has granted a Breakthrough Therapy Designation to tipifarnib for the treatment of patients with recurrent or metastatic HRAS-mutant head and neck squamous cell carcinoma with variant allele frequency ≥ 20% after disease progression on platinum-based chemotherapy.

Pre-Emptive Treatment May Be Superior to Reactive Treatment of Hand–Foot Reactions in mCRC

February 25, 2021

A preplanned analysis of the Regorafenib Dose Optimization Study in patients with metastatic colorectal cancer showed using pre-emptive clobetasol to treat hand–foot skin reactions was more effective than treating this adverse event reactively.

Leading Cancer Groups Release Recommendations to Close the Racial Health Care Gap

February 25, 2021

Three of the country’s leading health and cancer advocacy groups released recommendations on how to close the gap in racial health care disparities, which include increasing community engagement, improving access to care, addressing bias in care delivery, and providing quality and comprehensive care.

Can CDK4/6 Inhibitors Be Optimized for Breast Cancer?

February 25, 2021

Can treatment with inhibitors of cyclindependent kinases 4 and 6 be optimized for patients with breast cancer? This remains an open question 6 years after the first approval of a CDK4/6 inhibitor, palbociclib.

Concurrent Durvalumab Plus Radiation Shows Promise in Localized Urothelial Cancer

February 24, 2021

A promising efficacy signal was observed when the immune checkpoint inhibitor durvalumab was added concurrently to radiation followed by adjuvant durvalumab as treatment of patients with localized urothelial bladder cancer.

Promising 5-Year Outcomes Shown With CAR T-Cell Therapy in R/R B-Cell Lymphoma

February 24, 2021

For the treatment of relapsed or refractory aggressive B-cell lymphomas, chimeric antigen receptor–modified T-cell therapy is becoming more widely used. Still, little is known about outcomes for patients who receive CAR-modified T-cell therapy beyond 2 years.

Osimertinib Penetrates Blood-Brain Barrier and Decreases Metastasis in EGFR+ NSCLC

February 24, 2021

In with EGFR-mutant non–small cell lung cancer and brain metastases, oral osimertinib achieved rapid, high, and uniform brain exposure which was followed reduction in total brain metastases volume, according to results from the phase 1 ODIN-BM study.