Roundtable Roundup: First and Second Choices for Frontline RCC Therapy

CASE SUMMARY

• A 59-year-old African American woman was diagnosed with a left renal mass.
• She underwent left radical nephrectomy in December 2019.
  • Clear cell RCC
  • T3aN0Mx, International Society of Urological Pathology grade 3
• Nine months later, she reported pain in hips and left chest.
• Radiographic diagnosis: stage IV RCC with osteolytic lesions in iliac crest and left fifth rib
• ECOG performance status: 1
• Laboratory results:
  • Hemoglobin level: 11.1 g/dL
  • Elevated liver function test results
  • Mild hypercalcemia (10.8 mg/dL)
  • Neutrophil and platelet counts: within normal limits

CASE UPDATE

The patient received nivolumab (Opdivo) plus ipilimumab (Yervoy).