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Ovarian Cancer
Olaparib Shows PFS Benefit at 5-Year Follow-Up in BRCA Ovarian Cancer
September 18, 2020
Patients with newly diagnosed, advanced BRCA-mutated ovarian cancer who experienced complete or partial response following platinum-based chemotherapy continued to exhibit benefit in progression-free survival when receiving olaparib at long-term follow up versus placebo as first-line maintenance.
MEK Inhibitor Binimetinib Shows Limited Activity in Low-Grade Serous Ovarian Carcinomas
September 14, 2020
Binimetinib demonstrated activity as treatment of patients with low-grade serous ovarian carcinomas in the randomized phase 3 MILO/ENGOT-ov11 study.
Study Investigates Hydroxychloroquine and Itraconazole in Ovarian Cancer
July 28, 2020
Ainhoa Madariaga, MD, discusses the data from the phase 1/2 HYDRA-01 trial looking at hydroxychloroquine and itraconazole in patients with advanced platinum-resistant epithelial ovarian cancer.
A 71-Year-Old Woman With High-Risk Ovarian Cancer
July 14, 2020
Ramez N. Eskander, MD, explains the rationale for treating a 71-year-old woman with ovarian cancer with the PARP inhibitor rucaparib upon relapse.
Atezolizumab Plus Bevacizumab and Chemotherapy Falls Short of PFS Improvement in Phase 3 Ovarian Cancer Trial
July 13, 2020
The phase 3 IMagyn500 clinical trial failed to meet its primary end point of progression-free survival with the addition of atezolizumab to bevacizumab plus paclitaxel and carboplatin chemotherapy in patients with newly diagnosed advanced ovarian cancer.
Mirvetuximab Soravtansine Combination Improves Responses in Platinum-Agnostic Ovarian Cancer
June 24, 2020
Lucy Gilbert, MD, MSc, discusses the findings from a phase 1b trial in which mirvetuximab soravtansine was combined with bevacizumab in recurrent, high-grade epithelial ovarian cancer regardless of platinum sensitivity.
Mirvetuximab Plus Bevacizumab Combo Appears Durable in Platinum-Agnostic Ovarian Cancer
June 16, 2020
In an interview with Targeted Oncology, Lucy Gilbert, MD, MSc, discussed the interim findings for mirvetuximab in combination with bevacizumab as treatment of patients with platinum-agnostic ovarian cancer.
Frontline PARP Maintenance Study in Advanced Ovarian Cancer Ready to Start Treatment
June 11, 2020
“The completion of target patient enrollment in the Phase 3 ATHENA trial is an important milestone for Clovis and a critical step toward developing additional therapeutic options for women with advanced ovarian cancer."
Final ANANOVA2 Survival Data Support Niraparib Plus Bevacizumab in Recurrent Ovarian Cancer
May 31, 2020
Mansoor Raza Mirza, MD, discusses the final survival data from the randomized phase 2 NSGO-AVANOVA2/ENGOT-OV24 study, which evaluated the combination or niraparib plus bevacizumab versus niraparib alone in recurrent platinum-sensitive ovarian cancer.
Responses to Olaparib/Cediranib Combination in Ovarian Cancer Warrant Further Investigation
May 29, 2020
Despite missing the primary end point of progression-free survival improvement, cediranib and olaparib demonstrated comparable activity with platinum-based chemotherapy in patients with recurrent platinum-sensitive ovarian cancer.