Gynecologic Cancers

FDA Approves HPV Test With Extended Genotyping Capabilities

July 24, 2020

The expanded version of the BD Onclarity HPV Assay received approval for a pre-market approval supplement from the FDA, making it the only assay approved right now that individually identifies and reports human papillomavirus genotypes 31, 51, 52, 33/58, 35/39/68, and 56/59/66, as well as the standard 16,18, and 45.

Breast, Ovarian Screening Questionnaire Reveals Just 1 in 5 Women Meet NCCN Criteria for Genetic Testing

July 21, 2020

A pathogenic germline mutation rate of about 5% has been identified in women who had a family history of breast or ovarian cancer but no personal history of either disease.

Precision Medicine Guiding Ovarian Cancer Treatment

July 15, 2020

Sarah M. Temkin, MD leads discussion with Daphne B. Stewart, MD, around targeted therapies in ovarian cancer, whether offered in the academic or community setting.

Berzosertib Doublet Becomes First AFT inhibitor to Show Benefit in Platinum-Resistant High-Grade Serous Ovarian Cancer

July 15, 2020

The first randomized study of an ATR inhibitor in any malignancy demonstrated the benefit of berzosertib added to gemcitabine as treatment of patients with platinum-resistant high-grade serous ovarian cancer, according to a recently published study.

WEE-1 Inhibition Identified as a Potential Treatment Strategy for Recurrent Uterine Serous Carcinoma

July 11, 2020

In an interview with Targeted Oncology, Joyce F. Liu, MD, MPH, discussed the details of the phase 2 study of adavosertib in recurrent uterine serous carcinoma and the implications of this research for clinical practices.

Neoadjuvant Therapy Impresses in I-SPY 2 Trial for Breast Cancer

July 04, 2020

According to investigators on the phase 2 I-SPY 2 study, the addition durvalumab plus olaparib to treatment with neoadjuvant paclitaxel led to better pathologic complete response rates in patients with high-risk, HER2-negative stage II/III breast cancer compared with paclitaxel alone.

Randall Discusses Testing and Treatment Choices for Ovarian Cancer

July 03, 2020

Leslie M. Randall, MD, MAS, discussed the treatment regimens available for an African American patient with ovarian cancer.

Investigating Combinations in Recurrent or Metastatic Cervical Cancer

July 02, 2020

Bradley Monk, MD, discusses the phase 1b/2 innovaTV 205 trial in patients with recurrent or metastatic cervical cancer.

Trastuzumab Added to Chemotherapy Improves Survival in Uterine Serous Carcinoma

July 01, 2020

The addition of trastuzumab to chemotherapy in patients with uterine serous carcinoma had superior outcome compared with chemotherapy alone.

Tisotumab Induces Clinically Meaningful, Durable Responses in Recurrent Metastatic Cervical Cancer

June 30, 2020

"Available therapies upon progression after first-line chemotherapy in recurrent or metastatic cervical cancer are limited, and there is a significant unmet need for new treatment options."