Expert Guidance for Patients With PEComa and Sarcoma

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Thomas J. Herzog, MD, discusses the importance of patients seeing a gynecologist oncologist or a sarcoma doctor for gynecologic perivascular epithelioid sarcomas.

Thomas J. Herzog, MD, Paul & Carolyn Flory professor, University of Cincinnati, deputy director, University of Cincinnati Cancer Center, Cincinnati, OH, discusses the importance of patients seeing a gynecologist oncologist or a sarcoma doctor for gynecologic perivascular epithelioid sarcoma (PEComas).

During the 2024 Society of Gynecologic Oncology Annual Meeting, Herzog presented on nab-Sirolimus (Fyarro; ABI-009), the first and only FDA-approved treatment for locally advanced or metastatic malignant unresectable PEComa, and findings from a subgroup analysis of the phase 2 AMPECT study (NCT02494570) in patients with PEComa. In the study, nab-Sirolimus led to rapid and durable responses in patients with PEComa.

For those diagnosed with a PEComa, Herzog explains that the choice of where to seek treatment depends on factors like location and resources. Ideally, it is recommended to visit a high-volume gynecologist or a facility with a dedicated sarcoma program. Additionally, he explains that confirming the pathology and consulting with a physician experienced in treating sarcomas is crucial for creating an effective treatment plan.

Transcription:

0:09 | In terms of where to go if you have a PEComa, or even a sarcoma, I think it depends on obviously, where you live and what your resources are, and so forth. Ideally, you would go to a high volume gynecologist who treats a significant number of sarcomas. Or certainly if they have a sarcoma program, that is always a good choice as well.

0:32 | The key upon diagnosis of a sarcoma or PEComa is to make sure that the pathology is confirmed, and that you are seeing a physician who has high volume in sarcoma. That may be your gynecologic oncologist, or it may be a sarcoma specialist. I think either of those are great places to start. I do think that getting that expert opinion, though, is really key in getting the best outcome and treatment plan.

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