In this Targeted Oncology Practice Playbook program, Dr. Monty Pal provides a comprehensive overview of contemporary management strategies for advanced renal cell carcinoma (RCC), focusing on the practical application of evidence-based treatment algorithms in routine clinical practice. Drawing upon current clinical evidence, guideline recommendations, and his own clinical experience, Dr. Pal discusses key considerations that influence first-line treatment selection, including patient risk assessment, disease characteristics, treatment goals, and prior exposure to immunotherapy. He also outlines his approach to sequencing therapies following disease progression, emphasizing the importance of selecting the most appropriate initial treatment while individualizing subsequent therapy based on patient-specific factors, tolerability, and quality of life. Throughout the discussion, Dr. Pal reviews emerging clinical evidence that may influence future treatment paradigms, highlights ongoing challenges in translating clinical trial data into real-world practice, and shares practical insights intended to help community oncologists optimize care for patients with advanced renal cell carcinoma through thoughtful, personalized treatment decision making.
