CAR T-Cell Therapy | Clinical

University Hospitals Becomes First in Ohio to Offer 2 Types of CAR T-Cell Therapy

May 11, 2021

Two newly-approved CAR T-cell agents are now being used to treat patients with relapsed/refractory non-Hodgkin lymphoma and multiple myeloma at University Hospitals in Ohio.

Success of CAR T Cells in Blood Cancers Calls for Further Expansion into the Solid Tumor Arena

May 07, 2021

In an interview with Targeted Oncology, Bishop, discussed how CAR T cells have reshaped the treatment landscape, the future of their use, and their potential in solid tumors.

Investigating CAR T-Cell Therapy for Use in Different Disease Types

April 29, 2021

Michael Bishop, MD, discusses the investigations of and responses to chimeric antigen receptor T-cell therapy in different disease types.

FDA Removes Clinical Hold From NL-201, Allowing Launch of Study in R/R Solid Tumors

April 26, 2021

The FDA has removed the clinical hold on the investigational new drug application of NL-201, a treatment for relapsed or refractory tumors, allowing a phase 1 clinical trial to begin.

Liso-Cel Efficacy Not Impacted by Prior CD19 Exposure in LBCL

April 25, 2021

In an interview with Targeted Oncology, Scott R. Solomon, MD, a medical oncologist with the Blood and Marrow Transplant Program, Leukemia and Cellular Immunotherapy Program at the Northside Hospital Cancer Institute, discussed the efficacy of liso-cel in large B-cell lymphoma patients with prior anti-CD19 exposure and future research.

Lenzilumab Plus Axi-Cel Achieves Responses in 100% of Patients With DLBCL With Limited Toxicity in Small Study

April 23, 2021

When given at the recommended phase 2 dose, lenzilumab in combination with taxicabtagene ciloleucel, induced a 100% objective response rate while showing no severe cytokine release syndrome cases or severe neurotoxicity in patients with relapsed or refractory diffuse large B-cell lymphoma.

FDA Grants RMAT Designation to Novel Allogeneic CAR T-Cell Agent in Relapsed/Refractory Multiple Myeloma

April 21, 2021

The FDA has granted a regenerative medicine advanced therapy designation to the allogeneic chimeric antigen receptor T-cell therapy ALLO-715 for the treatment of relapsed or refractory multiple myeloma,.

Immune System Plays Important Role in CAR T Cell Responses in Glioblastoma Models

April 16, 2021

Chimeric antigen receptor T-cell therapy mediates antigen-dependent and -independent antitumor effects, and CAR T-cell activation of host antitumor immunity is critical for productive solid tumor CAR T immunotherapy.

CAR T-Cell Therapy Shows Consistent Safety and Pharmacokinetics in NHL

April 12, 2021

Scott R. Solomon, MD, discusses the adverse events and pharmacokinetics of lisocabtagene maraleucel in 12 patients with relapsed/refractory large B-cell non-Hodgkin lymphoma who had previously received anti-CD19 therapy.

Further Promise for CAR T-cell Therapy Use in R/R MCL Observed with Liso-Cel

March 24, 2021

In an interview with Targeted Oncology, Maria Lia Palomba, MD, a hematologic oncologist at Memorial Sloan Kettering Cancer Center, discussed the efficacy and safety of liso-cel in patients with R/R MCL as observed in the phase 1 TRANSCEND NHL 001 study.