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Lung Cancer | Clinical
Tazemetostat Results Signal the Utility of Biomarker-Driven Therapy for BAP1-Inactivated MPM
June 24, 2022
Results from a study of tazemetostat in patients with BAP1-inactivated malignant pleural mesothelioma show the feasibility of molecularly-stratified therapy for patients with relapsed or refractory disease.
Chemoimmunotherapy Shows 3-Year Survival Benefit for Advanced NSCLC
June 22, 2022
During a live virtual event, Adam J. Schoenfeld, MD, discussed the updated 3-year results of the CheckMate 9LA trial of nivolumab, ipilimumab, and 2 cycles of chemotherapy for patients with advanced non–small cell lung cancer.
Ramucirumab/Pembrolizumab Combo as Potential Treatment for NSCLC
June 16, 2022
Karen L. Reckamp, MD, discusses the Lung-MAP nonmatched substudy S1800A for patients with non–small cell lung cancer who were previously treated with immune checkpoint inhibitors and develop resistance.
Part 2: Considerations for Using Adjuvant Chemotherapy and Osimertinib in NSCLC
June 13, 2022
During a live virtual event, Aaron E. Lisberg, MD, discussed the use of adjuvant chemotherapy regimens and the significance of the ADAURA trial of osimertinib for patients with early-stage non–small cell lung cancer with certain EGFR mutations.
FDA Accepts sBLA for Pembrolizumab in Stage IB, II, or III NSCLC
June 13, 2022
A new supplemental biologics license application has been accepted by the FDA for pembrolizumab as treatment of patients with 1B (≥4 centimeters), 2, or 3 non-small cell lung cancer after complete surgical resection.
KEYNOTE-799 Results Reveal Durable Responses in Previously Untreated Stage III NSCLC
June 09, 2022
In patients with previously untreated, locally advanced stage III non–small cell lung cancer, continued benefit from pembrolizumab with concurrent chemoradiation followed by additional pembrolizumab was observed after more than 2 years of follow-up.
Sugemalimab Plus Chemotherapy Demonstrates Durable Efficacy as First-Line Treatment in Metastatic NSCLC
June 07, 2022
At the 2022 ASCO Annual Meeting, results from the GEMSTONE-302 trial showed that adding sugemalimab to chemotherapy improved survival in patients with metastatic non–small cell lung cancer.
Clinical Activity Shown With Patritumab Deruxtecan NSCLC Regardless of Identified Driver Genomic Alterations
June 07, 2022
According to Conor E. Steuer, MD, patritumab deruxtecan showed promising clinical activity in heavily pretreated patients with advanced non–small cell lung cancer with or without identified variant genomic alterations.
Brain Metastasis in Patients With NSCLC Correlates With Enrichment of CDKN2A/B and EGFR Mutations
June 06, 2022
Correlations between non–small cell lung cancer the metastasizes to the brain and enriched CDKN2A/B and EGFR alterations calls for further genomic exploration of this patient population.
Patients with NSCLC Experience Improved DFS with Pembrolizumab After Surgery
June 06, 2022
Adjuvant pembrolizumab led to improved disease-free survival versus placebo in patients with fully resected non–small cell lung cancer, according to second interim results from the PEARLS/KEYNOTE-091 trial.