In season 1, episode 3 of Targeted Talks, the importance of precision medicine in breast cancer, and how that vitally differs in community oncology compared with academic settings, is the topic of discussion. Stephanie L. Graff, MD, director of the Breast Program at the Sarah Cannon Cancer Institute HCA Midwest Health and associate director of the Breast Cancer Research Program at Sarah Cannon Research Institute in Nashville, Tennessee, leads the discussion with Gabriel N. Hortobagyi, MD, FACP, professor of medicine, Department of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, in Houston. The experts concluded from their conversation that the future of precision medicine in breast cancer currently lies with antibody-drug conjugates.

The conversation begins with both doctors explaining the history and the current state of precision medicine in breast cancer as well as the need for targeted therapies in this space to continue the growth of precision medicine. Graff and Hortobagyi also cover the role of genomic testing in aiding in the process of giving individualized care to patients with breast cancer. Ongoing research around targeted therapies in the space was a significant part of the genomic testing conversation, as is the unanswered questions around how to perform testing on these patients in both the community and in academic settings.

The in-depth part of the talk focuses on the novel targeted therapies that are being explored in clinical trials or are newly available in the clinical setting. The doctors specifically touch upon kinase inhibitor research and its use in practice, including drugs like lapatinib (Tykerb), neratinib (Nerlynx), tucatinib (Tukysa), and alpelisib (Piqray), as well as antibody-drug conjugates like ado-trastuzumab emtansine (T-DM1; Kadcyla), sacituzumab govitecan-hziy (Trodely), and trastuzumab deruxtecan (Enhertu). Targeted therapy combinations are also mentioned.

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In season 1, episode 3 of Targeted Talks, the importance of precision medicine in breast cancer, and how that vitally differs in community oncology compared with academic settings, is the topic of discussion.

Breast Cancer Leans into the Decade of Antibody-Drug Conjugates, Experts Discuss

In season 1, episode 2 of Targeted Talks, community physician Sarah M. Temkin, MD, a gynecologic oncologist at the Anne Arundel Medical Center in Annapolis, Maryland, leads a discussion with Daphne B. Stewart, MD, a medical oncologist and associate clinical professor at the City of Hope Comprehensive Cancer Center, in Duarte, California, around targeted therapies in ovarian cancer, whether offered in the academic or community setting.

The discussion covers the traditional methods for the frontline treatment of patients with recurrent ovarian cancer and how such methods compare with previous strategies and more modern strategies. Temkin and Stewart also touch upon the role of upfront genomic testing to provide precision medicine approaches to patients with germline or somatic 

 mutations, as well as those with homologous recombination deficiency. Although access to testing has improved over the years, they say, there are still barriers to getting access to testing for both germline and somatic mutations. The understanding of the necessity of dual testing and the results for homologous recombination deficiency testing also needs to be expanded, Stewart suggests.

As a conclusion to the topic, the experts review clinical trial research on single agents used for the treatment of patients in this population, in addition to combination therapies, and the management of toxicities from these treatment options.

Sarah M. Temkin, MD leads discussion with Daphne B. Stewart, MD, around targeted therapies in ovarian cancer, whether offered in the academic or community setting.


Precision Medicine Guiding Ovarian Cancer Treatment

In season 1, episode 1 of Targeted Talks, community physician Jason R. Williams, MD, DABR, interventional radiologist, Williams Cancer Institute, leads a discussion with George R. Simon, MD, FACP, FCCP, medical oncologist, The University of Texas MD Anderson Cancer Center, about the use of immunotherapy in patients with non–small cell lung cancer (NSCLC), whether treated in an academic or community setting, and how this could be challenged with the discovery of a genetic driver alteration.

During the discussion, the 2 experts cover the pros and cons of immunotherapy use and how they differ in the community setting versus the academic setting, the available tools for profiling patients, promising immune checkpoint inhibitors for the treatment of NSCLC, key genetic drivers in NSCLC, and choosing the optimal subsequent therapy for patients with NSCLC.

Community physician Jason Williams, MD, DABR, talks to academic oncologist George R. Simon, MD, FACO, FCCP, for an episode of Targeted Talks.

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