Key Takeaways on Treating Patients With EGFR+ NSCLC
Joshua K. Sabari, MD, offers key takeaways on treating patients with EGFR+ non–small cell lung cancer, highlighting the safety profile.
PAPILLON: Amivantamab Plus Chemotherapy in Patients With NSCLC Positive for EGFR Mutations
Expert insights on the treatment of patients with non–small cell lung cancer positive for EGFR mutations and what the PAPILLON study seeks to address.
Treatment Decision-Making for Patients With EGFR+ NSCLC
An expert on EGFR+ non–small cell lung cancer discusses factors that influence treatment decisions.
Updates from MARIPOSA Trial in EGFR+ NSCLC
An overview of recent data from the MARIPOSA trial investigating amivantamab plus lazertinib in patients with EGFR-positive advanced lung cancer.
EGFR+ NSCLC: Recent Data From FLAURA2
Joshua K. Sabari, MD, reviews clinical trial data from FLAURA2 on osimertinib plus chemotherapy in patients with EGFR-mutated advanced lung cancer.
Overview of Treatment Options for EGFR+ NSCLC
A medical oncologist provides an overview of treatment options available for patients with EGFR+ non–small cell lung cancer.
Patient Profile: A 73-Year-Old Man with EGFR+ NSCLC
Joshua K. Sabari, MD, reviews the patient profile of a 73-year-old patient with EGFR+ non–small cell lung cancer.
Next Steps to Evaluate LY3537982 in KRAS G12C-Mutant Solid Tumors
Joshua K. Sabari, MD, discusses where research on LY3537982 for patients with KRAS G12C-mutant advanced solid tumors is headed.
Sabari Reviews KRAS G12C Inhibitors in NSCLC
Joshua K. Sabari, MD, discusses the importance of targeting the KRAS biomarker and what inhibitors currently exist for patients with KRAS G12C-mutant advanced solid tumors.
Recent Progress and Unmet Needs in NSCLC
Dr. Florez and Dr. Sabari delve into areas of progress, unmet needs, and future research in NSCLC, encompassing novel biomarkers and targeted therapies such as CEACAM5.
Efficacy and Safety of Tusa with Pembrolizumab and Chemotherapy in NSCLC: CARMEN-LC05 Study
Important findings from the CARMEN-LC05 study evaluating tusa in combination with pembrolizumab and chemotherapy in NSCLC are discussed, highlighting their implications for clinical practice.
CARMEN-LC03 and CARMEN-LC04 Trials: Study Design and Anticipated Findings
An overview of the CARMEN-LC03 and CARMEN-LC04 trials investigating tusa in different treatment settings for NSCLC and their impact on treatment approaches is provided.
Phase 1 Study Shows Potential of LY3537982 in KRAS G12C NSCLC
Joshua K. Sabari, MD, discusses LY3537982 for patients with KRAS G12C-mutant advanced solid tumors.
Transforming the NSCLC Treatment Landscape with Antibody Drug Conjugates
The transformative potential of antibody drug conjugates in NSCLC treatment is discussed, encompassing their design, bystander effect, biomarkers, and impact on the treatment landscape.
Clinical Pearls: Treating Different Patient Populations in NSCLC
Dr. Florez and Dr. Sabari discuss standards of care for different patient populations in NSCLC.
CEACAM5 Testing in Clinical Practice
Experts share their approach to CEACAM5 testing, including the testing procedure, patient selection criteria, and timing of testing.
CEACAM5: Role, Expression, and Therapeutic Potential in NSCLC
The role of CEACAM5, its expression in NSCLC, and its potential as a therapeutic target are thoroughly examined, including its impact on tumorigenesis and prognosis in NSCLC patients.
Emerging Biomarkers and Targeted Therapies in NSCLC
The discussion centered around emergent biomarkers and targeted therapies in NSCLC, exploring targets like CEACAM5, TROP2, HER3, cMET, and the potential role of antibody drug conjugates in refractory disease.
Overview of the NSCLC Landscape, Prognosis, and Biomarker-Driven Treatments
A comprehensive overview of the current landscape of non-small cell lung cancer (NSCLC), highlighting the impact of biomarkers on treatment selection.
Assessing LY3537982 for KRAS G12C-Mutant Advanced Solid Tumors
Navigating Through the Carboplatin Shortage
Joshua K. Sabari, MD, discusses the shortage of carboplatin, its impacts, and how oncologist can still treat patients.
Impact of COVID-19 on Oncology Drug Shortages
Joshua K. Sabari, MD, explains how the shortage of drugs in the oncology space, including carboplatin and cisplatin, began.
Discussing When to Use Durvalumab in SCLC
Joshua K. Sabari, MD, discusses his use of durvalumab in the frontline setting for the treatment of patients with small-cell lung cancer and where he sees the role for the treatment.
Advice for Community Oncologists who Treat Patients with NSCLC
Mark Socinski, MD and Joshua Sabari, MD, share their insight for community oncologists who treat patients with KRASG12C-mutated NSCLC with CNS metastases.
Potential Shift of KRASG12C Inhibitors to the Front-line Setting
Two experts discuss the potential role of using adagrasib and sotorasib in the front-line setting and how it might shift the treatment paradigm for patients with KRASG12C-mutated NSCLC with CNS metastases.
Use of Sotorasib in Patients with KRASG12C mutated NSCLC
Drs Socinski and Sabari comment on the use of sotorasib in patients with KRASG12C-mutated NSCLC with brain metastases and review data from the CodeBreak 100 and CodeBreak 200 trials.
Review of KRYSTAL 1b and Role of Adagrasib in Patients With Untreated CNS Metastases
Mark Socinski, MD and Joshua Sabari, MD review the key efficacy data from the KRYSTAL 1b cohort and discusses strategies for managing adverse events seen with adagrasib.
KRASG12C Mutations and CNS Metastases in Patients with NSCLC
Drs Socinski and Sabari discuss the emergence of the KRAS12C mutation, specifically in patients with CNS metastases and how this factors into their treatment decision.
Different Types of Biomarker Testing Methods Used in Patients with NSCLC
Drs Socinski and Sabari explain the different types of testing methods commonly used in their clinical practice and share advice for community oncologists who are testing for biomarkers in their patients with NSCLC.
Importance of Biomarker Testing in Patients with NSCLC
Two experts discuss the evolving treatment landscape for patients with non-small cell lung cancer (NSCLC) and reviews the role of molecular testing and discusses some of the challenges faced.
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