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Opinion|Videos|November 18, 2024

Prospects in First-Line and Maintenance Settings

Joshua K. Sabari, MD, evaluates the potential of ifinatamab deruxtecan in combination with atezolizumab, with or without platinum-based chemotherapy, as first-line induction or maintenance therapy in ES-SCLC, emphasizing that statistically significant end points such as improved PFS and OS would be essential for clinical application in this patient population.

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Video content above is prompted by the following:

Given the currently available data on ifinatamab deruxtecan, please evaluate its potential in combination with atezolizumab with or without platinum-based chemotherapy as first-line induction or maintenance therapy in ES-SCLC.

  • What would you consider to be statistically significant end points with dual or triple therapy to warrant clinical application in this patient population?

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