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Opinion|Videos|October 28, 2024

B7-H3 Mechanism and Therapeutic Potential

Joshua K. Sabari, MD, discusses the unique mechanism of action of B7-H3, highlighting its role as an immune checkpoint regulator that is overexpressed in SCLC and associated with poor prognosis. He notes that B7-H3 blockade can enhance CD8-positive T-cell activity and may serve as a promising treatment option for SCLC that has progressed after platinum-based chemotherapy.

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Please discuss the unique mechanism of action of B7-H3 and its treatment potential as subsequent therapy for SCLC that has progressed after platinum-based chemotherapy.

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