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Opinion|Videos|November 18, 2024

Mechanism of Action Compared With Other Alkylating Agents

Joshua K. Sabari, MD, describes the mechanism of action of lurbinectedin as a synthetic alkaloid that binds to guanine residues in the minor groove of DNA, forming adducts that disrupt DNA repair mechanisms and promote apoptosis in cancer cells, noting that its action contrasts with traditional alkylating agents by specifically interfering with DNA-protein interactions and transcription processes.

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Briefly describe the mechanism of action of lurbinectedin and how it might compare or contrast with other alkylating agents in the treatment of SCLC.

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