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Opinion|Videos|October 7, 2024

Mechanism of Action of BiTE Immunotherapy

Author(s)Joshua K. Sabari, MD

Joshua K. Sabari, MD, discusses how tarlatamab, a BiTE, demonstrates a unique mechanism of action by targeting DLL3, which is aberrantly expressed in 85% to 94% of SCLC cells, thereby directing T cells to these cancer cells independently of MHC class I and promoting T-cell–mediated tumor lysis and regression.

Episodes in this series

EP. 1 Clinical Impressions and Therapy Goals

EP. 1 Clinical Impressions and Therapy Goals

EP. 2 Considerations for Extended Chemoimmunotherapy

EP. 2 Considerations for Extended Chemoimmunotherapy

EP. 3 Prophylactic Cranial Irradiation Considerations

EP. 3 Prophylactic Cranial Irradiation Considerations

EP. 4 Mechanism of Action of BiTE Immunotherapy

EP. 4 Mechanism of Action of BiTE Immunotherapy

EP. 5 Interpreting DeLLphi-301 Trial Results: ORR, Duration of Response, and Long-Term Outcomes

EP. 5 Interpreting DeLLphi-301 Trial Results: ORR, Duration of Response, and Long-Term Outcomes

EP. 6 Significance of Durable Responses in DeLLphi-301 Trial

EP. 6 Significance of Durable Responses in DeLLphi-301 Trial

$EP. 7 Expectations for PFS and OS in Relapsed/Refractory SCLC$

EP. 7 Expectations for PFS and OS in Relapsed/Refractory SCLC

EP. 8 Future Potential in Combination Therapies

EP. 8 Future Potential in Combination Therapies

EP. 9 Dual Maintenance With BiTE and PD-L1 Inhibitors

EP. 9 Dual Maintenance With BiTE and PD-L1 Inhibitors

EP. 10 B7-H3 Mechanism and Therapeutic Potential

EP. 10 B7-H3 Mechanism and Therapeutic Potential

EP. 11 Current Practices in B7-H3 Testing

EP. 11 Current Practices in B7-H3 Testing

EP. 12 Interpreting IDeate-Lung02 Trial Outcomes

EP. 12 Interpreting IDeate-Lung02 Trial Outcomes

EP. 13 Comparing Dosing Schedules With Standard Therapies

EP. 13 Comparing Dosing Schedules With Standard Therapies

EP. 14 Potential Synergies With T-Cell Engagers

EP. 14 Potential Synergies With T-Cell Engagers

EP. 15 Prospects in First-Line and Maintenance Settings

EP. 15 Prospects in First-Line and Maintenance Settings

EP. 16 Mechanism of Action Compared With Other Alkylating Agents

EP. 16 Mechanism of Action Compared With Other Alkylating Agents

EP. 17 Efficacy in Platinum-Sensitive vs Platinum-Resistant SCLC

EP. 17 Efficacy in Platinum-Sensitive vs Platinum-Resistant SCLC

EP. 18 Comparative Efficacy and Future Directions in SCLC Treatment

EP. 18 Comparative Efficacy and Future Directions in SCLC Treatment

Video content above is prompted by the following:

Please discuss the unique mechanism of action of tarlatamab, a BiTE, and its treatment potential as subsequent therapy for SCLC that has progressed after platinum-based chemotherapy.

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