EGFR+ Lung Cancer | Clinical

Plinabulin Plus Docetaxel Combination Succeeds in Improving OS in NSCLC With EGFR Wild Type

August 04, 2021

The combination of plinabulin with docetaxel showed improvement in overall survival compared with docetaxel alone as treatment of patients with second- and third-line non –small cell lung cancer with EGFR wild type, meeting the primary end point of the phase 3 DUBLIN-3 clinical trial.

Precise Management of EGFR exon 20-Positive Non–Small Cell Lung Cancer

July 26, 2021

Research shows that methods used to treat the wide epidermal growth factor receptor-positive population are often not successful for patients with specific biomarkers like EGFR exon 20 insertion mutations, highlighting an ongoing need for more targeted therapies.

High BMI Negatively Impacts Survival Outcomes With Osimertinib in EGFR+ NSCLC

July 05, 2021

In a retrospective analysis of patients with advanced non–small cell lung cancer and EGFR mutations treated with osimertinib, investigators found that body mass index of 25 kg/mq2 or more had a negative impact on survival outcomes.

The Safety Profile of Amivantamab and Lazertinib in EGFR-Mutant NSCLC

June 06, 2021

Alexander Spira, MD, PhD, FACP, director of the Virginia Cancer Specialists Research Institute, discusses the safety profile of amivantamab and lazertinib in EGFR-mutated non-small cell lung cancer, based on data from the CHRYSALIS tria.