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Opinion|Videos|April 2, 2025

HER2-Mutated NSCLC: Second-Line Treatment Selection and Emerging Approaches

Author(s)Joshua K. Sabari, MD, Christine Bestvina, MD , Mark Kris, MD

Panelists discuss second-line treatment options and emerging approaches for HER2-mutated non–-small cell lung cancer (NSCLC), highlighting novel therapies and clinical strategies.

Episodes in this series

EP. 1 Overview: Actionable Alterations in NSCLC

EP. 1 Overview: Actionable Alterations in NSCLC

EP. 2 Molecular Testing for Metastatic NSCLC

EP. 2 Molecular Testing for Metastatic NSCLC

EP. 3 Metastatic NSCLC: Decision-Making When Molecular Testing Results Are Delayed

EP. 3 Metastatic NSCLC: Decision-Making When Molecular Testing Results Are Delayed

EP. 4 Use of RNA-Based Molecular Panels in Metastatic NSCLC

EP. 4 Use of RNA-Based Molecular Panels in Metastatic NSCLC

EP. 5 Case 1 Presentation—KRAS-Mutated Metastatic NSCLC: First-Line Decision- Making

EP. 5 Case 1 Presentation—KRAS-Mutated Metastatic NSCLC: First-Line Decision- Making

EP. 6 Case Presentation: Second-Line Decision- Making for KRAS-Mutated Metastatic NSCLC

EP. 6 Case Presentation: Second-Line Decision- Making for KRAS-Mutated Metastatic NSCLC

EP. 7 KRAS Inhibitors for NSCLC: Efficacy and Safety

EP. 7 KRAS Inhibitors for NSCLC: Efficacy and Safety

EP. 8 KRAS-Mutated Metastatic NSCLC: Individualized Treatment Selection

EP. 8 KRAS-Mutated Metastatic NSCLC: Individualized Treatment Selection

EP. 9 KRAS Inhibition: On the Horizon

EP. 9 KRAS Inhibition: On the Horizon

EP. 10 Case 2—Metastatic NSCLC With a ROS1 Alteration: Presentation and Discussion

EP. 10 Case 2—Metastatic NSCLC With a ROS1 Alteration: Presentation and Discussion

EP. 11 Next-Generation ROS1 Inhibition

EP. 11 Next-Generation ROS1 Inhibition

EP. 12 Treatment Decision-Making for Metastatic NSCLC With a ROS1 Alteration

EP. 12 Treatment Decision-Making for Metastatic NSCLC With a ROS1 Alteration

EP. 13 ROS1 Inhibition: AE Management

EP. 13 ROS1 Inhibition: AE Management

EP. 14 Case 2 (cont.)—Metastatic NSCLC With a ROS1 Alteration: Patients With CNS Disease

EP. 14 Case 2 (cont.)—Metastatic NSCLC With a ROS1 Alteration: Patients With CNS Disease

EP. 15 Case 3—HER2-Mutated Metastatic NSCLC: Presentation and Discussion

EP. 15 Case 3—HER2-Mutated Metastatic NSCLC: Presentation and Discussion

EP. 16 HER2 Mutations in NSCLC

EP. 16 HER2 Mutations in NSCLC

EP. 17 HER2-Mutated NSCLC: Second-Line Treatment Selection and Emerging Approaches

EP. 17 HER2-Mutated NSCLC: Second-Line Treatment Selection and Emerging Approaches

EP. 18 Management of ADC-Related AEs

EP. 18 Management of ADC-Related AEs

EP. 19 Case 3 (cont.): Management of Treatment-Associated ILD/Pneumonitis

EP. 19 Case 3 (cont.): Management of Treatment-Associated ILD/Pneumonitis

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