NEWS
CONFERENCES
MEDIA
PUBLICATIONS
CASE-BASED ROUNDTABLE
PARTNERS
RESOURCES
SUBSCRIBE

Your AI-Trained Oncology Knowledge Connection!

Opinion|Videos|February 26, 2025

KRAS Inhibitors for NSCLC: Efficacy and Safety

Author(s)Joshua K. Sabari, MD, Christine Bestvina, MD , Mark Kris, MD

Panelists discuss the efficacy and safety of KRAS inhibitors for non–-small cell lung cancer (NSCLC), evaluating clinical trial results and their potential impact on treatment strategies.

Episodes in this series

EP. 1 Overview: Actionable Alterations in NSCLC

EP. 1 Overview: Actionable Alterations in NSCLC

EP. 2 Molecular Testing for Metastatic NSCLC

EP. 2 Molecular Testing for Metastatic NSCLC

EP. 3 Metastatic NSCLC: Decision-Making When Molecular Testing Results Are Delayed

EP. 3 Metastatic NSCLC: Decision-Making When Molecular Testing Results Are Delayed

EP. 4 Use of RNA-Based Molecular Panels in Metastatic NSCLC

EP. 4 Use of RNA-Based Molecular Panels in Metastatic NSCLC

EP. 5 Case 1 Presentation—KRAS-Mutated Metastatic NSCLC: First-Line Decision- Making

EP. 5 Case 1 Presentation—KRAS-Mutated Metastatic NSCLC: First-Line Decision- Making

EP. 6 Case Presentation: Second-Line Decision- Making for KRAS-Mutated Metastatic NSCLC

EP. 6 Case Presentation: Second-Line Decision- Making for KRAS-Mutated Metastatic NSCLC

EP. 7 KRAS Inhibitors for NSCLC: Efficacy and Safety

EP. 7 KRAS Inhibitors for NSCLC: Efficacy and Safety

EP. 8 KRAS-Mutated Metastatic NSCLC: Individualized Treatment Selection

EP. 8 KRAS-Mutated Metastatic NSCLC: Individualized Treatment Selection

EP. 9 KRAS Inhibition: On the Horizon

EP. 9 KRAS Inhibition: On the Horizon

EP. 10 Case 2—Metastatic NSCLC With a ROS1 Alteration: Presentation and Discussion

EP. 10 Case 2—Metastatic NSCLC With a ROS1 Alteration: Presentation and Discussion

EP. 11 Next-Generation ROS1 Inhibition

EP. 11 Next-Generation ROS1 Inhibition

EP. 12 Treatment Decision-Making for Metastatic NSCLC With a ROS1 Alteration

EP. 12 Treatment Decision-Making for Metastatic NSCLC With a ROS1 Alteration

EP. 13 ROS1 Inhibition: AE Management

EP. 13 ROS1 Inhibition: AE Management

EP. 14 Case 2 (cont.)—Metastatic NSCLC With a ROS1 Alteration: Patients With CNS Disease

EP. 14 Case 2 (cont.)—Metastatic NSCLC With a ROS1 Alteration: Patients With CNS Disease

EP. 15 Case 3—HER2-Mutated Metastatic NSCLC: Presentation and Discussion

EP. 15 Case 3—HER2-Mutated Metastatic NSCLC: Presentation and Discussion

EP. 16 HER2 Mutations in NSCLC

EP. 16 HER2 Mutations in NSCLC

EP. 17 HER2-Mutated NSCLC: Second-Line Treatment Selection and Emerging Approaches

EP. 17 HER2-Mutated NSCLC: Second-Line Treatment Selection and Emerging Approaches

EP. 18 Management of ADC-Related AEs

EP. 18 Management of ADC-Related AEs

EP. 19 Case 3 (cont.): Management of Treatment-Associated ILD/Pneumonitis

EP. 19 Case 3 (cont.): Management of Treatment-Associated ILD/Pneumonitis

Newsletter

Stay up to date on practice-changing data in community practice.

Related Content

Two experts are featured in this series.

Long-Term Outcomes of the RELATIVITY-047 Trial

ByIsabella Glitza de Oliva, MD, PhD, MS,Elizabeth Burton, PhD, MBA

November 7th 2025

Dose Modifications and Treatment Sequencing

ByAlexander Spira, MD, PhD

November 6th 2025

Safety, Tolerability, and Adverse Event Management

ByAlexander Spira, MD, PhD

November 6th 2025

Two experts are featured in this series.

Frontline Treatment Options for Advanced Melanoma

ByIsabella Glitza de Oliva, MD, PhD, MS,Elizabeth Burton, PhD, MBA

October 31st 2025

Case Description and Molecular Testing in EGFR-Mutant NSCLC

ByAlexander Spira, MD, PhD

October 30th 2025

Latest CME

23rd Annual School of Breast Oncology

In-Person Event

23rd Annual School of Breast Oncology

November 6-8, 2025

Community Practice Connections™: Navigating Early-Stage HR+/HER2‒- Breast Cancer – Clinical Developments and Innovative Treatments

Community Practice Connections™: Navigating Early-Stage HR+/HER2‒- Breast Cancer – Clinical Developments and Innovative Treatments

Neil M. Iyengar, MD; Komal Jhaveri, MD, FACP

Breast Cancer Symposia in San Antonio

In-Person + Virtual Event

Breast Cancer Symposia in San Antonio

December 8-11, 2025

Community Practice Connections™: Community Oncologists’ Role in Selecting Optimal Oral SERD Treatment for HR+/HER2- Breast Cancer

Community Practice Connections™: Community Oncologists’ Role in Selecting Optimal Oral SERD Treatment for HR+/HER2- Breast Cancer

Virginia Kaklamani, MD, DSc; William J Gradishar, MD, FASCO, FACP

Community Practice Connections™: Case Discussions in TNBC… Navigating the Latest Advances and Impact of Disparities in Care

Community Practice Connections™: Case Discussions in TNBC… Navigating the Latest Advances and Impact of Disparities in Care

Tiffany A. Traina, MD, FASCO; Demetria Smith-Graziani, MD, MPH

Medical Crossfire®: Improving Survival in HR-Positive HER2-Negative Metastatic Breast Cancer – Advances in Selective Estrogen Receptor Targeting Therapies

Medical Crossfire®: Improving Survival in HR-Positive HER2-Negative Metastatic Breast Cancer – Advances in Selective Estrogen Receptor Targeting Therapies

Aditya Bardia, MD, MPH; Heather McArthur, MD, MPH; Sonya Reid, MD, MPH

Inaugural Brain & Spine Metastases Conference: Evolving Practice and Emerging Therapies

In-Person Event

Inaugural Brain & Spine Metastases Conference: Evolving Practice and Emerging Therapies

January 22, 2026

2nd Annual Hawaii Cancer Conference

In-Person Event

2nd Annual Hawaii Cancer Conference

January 24-25, 2026

42nd Annual CFS: Chemotherapy Foundation Symposium®: Innovative Cancer Therapy for Tomorrow

42nd Annual CFS: Chemotherapy Foundation Symposium®: Innovative Cancer Therapy for Tomorrow

Benjamin P. Levy, MD; John O. Mascarenhas, MD; Tiffany A. Traina, MD, FASCO; Cathy Eng, MD, FACP, FASCO; John P. Leonard, MD

The Inaugural Hawaii Breast Cancer: A Multidisciplinary Case-Based Conference

The Inaugural Hawaii Breast Cancer: A Multidisciplinary Case-Based Conference

Hope S. Rugo, MD, FASCO; Naoto T. Ueno, MD, PhD

43rd Annual Miami Breast Cancer Conference®

In-Person Event

43rd Annual Miami Breast Cancer Conference®

March 5-8, 2026

Medical Crossfire®: Translating Evidence to Clinical Practice in Early-Stage HR+, HER2– Breast Cancer

Medical Crossfire®: Translating Evidence to Clinical Practice in Early-Stage HR+, HER2– Breast Cancer

Joyce O’Shaughnessy, MD; William J. Gradishar, MD, FASCO, FACP; Heather McArthur, MD, MPH

Updates and Innovations in Nonopioid Pain Management Strategies for Breast Cancer Patients Postsurgical Intervention

Updates and Innovations in Nonopioid Pain Management Strategies for Breast Cancer Patients Postsurgical Intervention

Patrick I. Borgen, MD; Joshua Feinberg, MD; Gary Schwartz, MD, FASA

Shaping Surgical Pathways: Revolutionizing Breast Cancer Care With Genetic Testing and Targeted Treatment

Shaping Surgical Pathways: Revolutionizing Breast Cancer Care With Genetic Testing and Targeted Treatment

Patrick I. Borgen, MD; E. Shelley Hwang, MD, MPH; Mark E. Robson, MD

Community Practice Connections™: Translating Evidence to Clinical Practice in Early-Stage HR+, HER2- Breast Cancer

Community Practice Connections™: Translating Evidence to Clinical Practice in Early-Stage HR+, HER2- Breast Cancer

Joyce O’Shaughnessy, MD; William Gradishar, MD, FASCO, FACP; Heather McArthur, MD, MPH; Eleni Anastasia Tousimis, MD, MBA, FACS

Community Practice Connections™: Optimizing Treatment Outcomes and Preserving Fertility in Premenopausal HR+ Breast Cancer

Community Practice Connections™: Optimizing Treatment Outcomes and Preserving Fertility in Premenopausal HR+ Breast Cancer

Rebecca Shatsky, MD; Kelly McCann, MD, PhD; Michelle L. Taylor, ANP-BC

Community Practice Connections™: Exploring Emerging Next-Generation Endocrine Therapies in ER+/HER2- Breast Cancer – Evaluating the Potential of Future of Treatment

Community Practice Connections™: Exploring Emerging Next-Generation Endocrine Therapies in ER+/HER2- Breast Cancer – Evaluating the Potential of Future of Treatment

Heather McArthur, MD, MPH; Komal Jhaveri, MD, FACP; Sara Tolaney, MD, MPH; Seth A. Wander, MD, PhD

Community Practice Connections™: Navigating the Impact of HER2, HER3 and TROP2 from Early Stage to Advanced Breast Cancer Care

Community Practice Connections™: Navigating the Impact of HER2, HER3 and TROP2 from Early Stage to Advanced Breast Cancer Care

Hope S. Rugo, MD, FASCO; Sara Hurvitz, MD, FACP; Jennifer Litton, MD, MHCM; Heather McArthur, MD, MPH

Innovations in HR+/HER2– Metastatic Breast Cancer: Advancing Care Through PROTAC ER Degradation

Innovations in HR+/HER2– Metastatic Breast Cancer: Advancing Care Through PROTAC ER Degradation

Rita Nanda, MD; William Gradishar, MD, FASCO, FACP; Komal Jhaveri, MD, FACP; Kevin Kalinsky, MD, MS

Clinical Case Vignette Series™: 42nd Annual Miami Breast Cancer Conference®

Clinical Case Vignette Series™: 42nd Annual Miami Breast Cancer Conference®

Reshma Jagsi, MD, DPhil; Kevin Kalinsky, MD, MS; Hope S. Rugo, MD, FASCO; Alastair Thompson, MD, MBChB, BSc (Hons), FRCS (Ed), FACS

Breast Cancer Tumor Board®: Advancing Care in Metastatic Breast Cancer - The Evolving Role of Antibody-Drug Conjugates

Breast Cancer Tumor Board®: Advancing Care in Metastatic Breast Cancer - The Evolving Role of Antibody-Drug Conjugates

Aditya Bardia, MD, MPH, FASCO; Joyce O’Shaughnessy, MD; Hope S. Rugo, MD; Paolo Tarantino, MD

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

William J. Gradishar, MD, FASCO, FACP; Laura Huppert, MD; Yuan Yuan, MD, PhD

25th Annual International Congress on the Future of Breast Cancer® East

In-Person Event

25th Annual International Congress on the Future of Breast Cancer® East

July 10-11, 2026

25th Annual International Congress on the Future of Breast Cancer® West

In-Person Event

25th Annual International Congress on the Future of Breast Cancer® West

July 17-18, 2026

Breast Cancer Tumor Board: Targeting TROP2 – Innovations in Triple-Negative Breast Cancer Treatment

Breast Cancer Tumor Board: Targeting TROP2 – Innovations in Triple-Negative Breast Cancer Treatment

Joyce O’Shaughnessy, MD; Matthew P. Goetz, MD; Hope S. Rugo, MD, FASCO

Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Expert Guidance on Frequently Asked Questions Regarding the Use of ADCs in TNBC

Expert Guidance on Frequently Asked Questions Regarding the Use of ADCs in TNBC

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc

Evaluating the Latest Data and Ongoing Trials for Novel ADC Approaches in TNBC

Evaluating the Latest Data and Ongoing Trials for Novel ADC Approaches in TNBC

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD

Establishing the Rationale for ADC and ICI Combinations in TNBC

Establishing the Rationale for ADC and ICI Combinations in TNBC

Virginia Kaklamani, MD, DSc; Tiffany A. Traina, MD, FASCO

Breaking Down the Rationale for Targeting TROP2 in TNBC

Breaking Down the Rationale for Targeting TROP2 in TNBC

Filipa Lynce, MD; Rita Nanda, MD

24th Annual International Congress on the Future of Breast Cancer® East

24th Annual International Congress on the Future of Breast Cancer® East

Joyce O’Shaughnessy, MD

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc; Filipa Lynce, MD; Rita Nanda, MD; Tiffany A. Traina, MD, FASCO

Show Me the Data®: New and Emerging Roles for Oral SERD Therapy in the Treatment of ER+/HER2– Breast Cancer

Show Me the Data®: New and Emerging Roles for Oral SERD Therapy in the Treatment of ER+/HER2– Breast Cancer

Ana C. Garrido-Castro, MD; Pedram Razavi, MD, PhD

Expert Roundtable and Panel Discussions: Current and Future Landscape of TNBC

Expert Roundtable and Panel Discussions: Current and Future Landscape of TNBC

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Tiffany A. Traina, MD, FASCO

School of Breast Oncology® (SOBO) Slide & Lecture Library

SOBO Slide Library

School of Breast Oncology® (SOBO) Slide & Lecture Library

Joyce O’Shaughnessy, MD

Trending on Targeted Oncology - Immunotherapy, Biomarkers, and Cancer Pathways

Sacituzumab Govitecan Misses PFS in First-Line HR+/HER2– Metastatic Breast Cancer

First-in-Human Data Support Izalontamab in Advanced Epithelial Tumors

FDA Approves Subcutaneous Daratumumab for Smoldering Multiple Myeloma

COSMIC-313 Trial: KIM-1 Associated With Clinical Outcomes in Advanced RCC

Lurbinectedin and Tarlatamab in ES-SCLC

© 2025 MJH Life Sciences^®

All rights reserved.