NEWS
CONFERENCES
MEDIA
PUBLICATIONS
CASE-BASED ROUNDTABLE
PARTNERS
RESOURCES
SUBSCRIBE

Opinion|Videos|April 2, 2025

HER2 Mutations in NSCLC

Author(s)Joshua K. Sabari, MD, Christine Bestvina, MD , Mark Kris, MD

Panelists discuss the role of HER2 mutations in non–-small cell lung cancer (NSCLC), focusing on diagnostic approaches, clinical implications, and targeted treatment strategies.

Episodes in this series

EP. 1 Overview: Actionable Alterations in NSCLC

EP. 1 Overview: Actionable Alterations in NSCLC

EP. 2 Molecular Testing for Metastatic NSCLC

EP. 2 Molecular Testing for Metastatic NSCLC

EP. 3 Metastatic NSCLC: Decision-Making When Molecular Testing Results Are Delayed

EP. 3 Metastatic NSCLC: Decision-Making When Molecular Testing Results Are Delayed

EP. 4 Use of RNA-Based Molecular Panels in Metastatic NSCLC

EP. 4 Use of RNA-Based Molecular Panels in Metastatic NSCLC

EP. 5 Case 1 Presentation—KRAS-Mutated Metastatic NSCLC: First-Line Decision- Making

EP. 5 Case 1 Presentation—KRAS-Mutated Metastatic NSCLC: First-Line Decision- Making

EP. 6 Case Presentation: Second-Line Decision- Making for KRAS-Mutated Metastatic NSCLC

EP. 6 Case Presentation: Second-Line Decision- Making for KRAS-Mutated Metastatic NSCLC

EP. 7 KRAS Inhibitors for NSCLC: Efficacy and Safety

EP. 7 KRAS Inhibitors for NSCLC: Efficacy and Safety

EP. 8 KRAS-Mutated Metastatic NSCLC: Individualized Treatment Selection

EP. 8 KRAS-Mutated Metastatic NSCLC: Individualized Treatment Selection

EP. 9 KRAS Inhibition: On the Horizon

EP. 9 KRAS Inhibition: On the Horizon

EP. 10 Case 2—Metastatic NSCLC With a ROS1 Alteration: Presentation and Discussion

EP. 10 Case 2—Metastatic NSCLC With a ROS1 Alteration: Presentation and Discussion

EP. 11 Next-Generation ROS1 Inhibition

EP. 11 Next-Generation ROS1 Inhibition

EP. 12 Treatment Decision-Making for Metastatic NSCLC With a ROS1 Alteration

EP. 12 Treatment Decision-Making for Metastatic NSCLC With a ROS1 Alteration

EP. 13 ROS1 Inhibition: AE Management

EP. 13 ROS1 Inhibition: AE Management

EP. 14 Case 2 (cont.)—Metastatic NSCLC With a ROS1 Alteration: Patients With CNS Disease

EP. 14 Case 2 (cont.)—Metastatic NSCLC With a ROS1 Alteration: Patients With CNS Disease

EP. 15 Case 3—HER2-Mutated Metastatic NSCLC: Presentation and Discussion

EP. 15 Case 3—HER2-Mutated Metastatic NSCLC: Presentation and Discussion

EP. 16 HER2 Mutations in NSCLC

EP. 16 HER2 Mutations in NSCLC

EP. 17 HER2-Mutated NSCLC: Second-Line Treatment Selection and Emerging Approaches

EP. 17 HER2-Mutated NSCLC: Second-Line Treatment Selection and Emerging Approaches

EP. 18 Management of ADC-Related AEs

EP. 18 Management of ADC-Related AEs

EP. 19 Case 3 (cont.): Management of Treatment-Associated ILD/Pneumonitis

EP. 19 Case 3 (cont.): Management of Treatment-Associated ILD/Pneumonitis

Newsletter

Stay up to date on practice-changing data in community practice.

Related Content

Advanced Renal Cell Carcinoma: Tailoring Second-Line Therapy After Prior Immunotherapy

BySumanta (Monty) Kumar Pal, MD, FASCO

July 23rd 2026

Advanced Renal Cell Carcinoma: Practical Sequencing Strategies Following First-Line Therapy

BySumanta (Monty) Kumar Pal, MD, FASCO

July 23rd 2026

Advanced Renal Cell Carcinoma: Summarizing a Practical First-Line Treatment Algorithm

BySumanta (Monty) Kumar Pal, MD, FASCO

July 16th 2026

Advanced Renal Cell Carcinoma: Integrating Prior Adjuvant Immunotherapy into First-Line Treatment Decisions

BySumanta (Monty) Kumar Pal, MD, FASCO

July 16th 2026

Experts featured in this series.

Multidisciplinary Supportive Care and Unmet Needs in ROS1-Positive Advanced Non-Small Cell Lung Cancer

ByEric Singhi, MD,Bruna Pellini, MD,Estelamari Rodriguez, MD, MPH,Gregory Riedlinger, MD, PhD,Idalmis Hernandez. NP

July 9th 2026

Latest CME

Breast Cancer Tumor Board: Targeting TROP2 – Innovations in Triple-Negative Breast Cancer Treatment

Breast Cancer Tumor Board: Targeting TROP2 – Innovations in Triple-Negative Breast Cancer Treatment

Joyce O’Shaughnessy, MD; Matthew P. Goetz, MD; Hope S. Rugo, MD, FASCO

Empire State Hematology & Oncology Society (New York)

Empire State Hematology & Oncology Society (New York)

2 Sessions are Available!

Minnesota Society of Clinical Oncology

Minnesota Society of Clinical Oncology

2 Sessions are Available!

South Carolina Oncology Society

South Carolina Oncology Society

2 Sessions are Available!

Community Oncology Connections™: Monotherapies vs Combinations – Navigating Oral SERDs and Targeted Combination Strategies in HR+/HER2– Metastatic Breast Cancer | Kansas Society of Clinical Oncology

Community Oncology Connections™: Monotherapies vs Combinations – Navigating Oral SERDs and Targeted Combination Strategies in HR+/HER2– Metastatic Breast Cancer | Kansas Society of Clinical Oncology

Aditya Bardia, MD, MPH, FASCO; Bachar Samra, MD

Expert Guidance on Frequently Asked Questions Regarding the Use of ADCs in TNBC

Expert Guidance on Frequently Asked Questions Regarding the Use of ADCs in TNBC

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc

Establishing the Rationale for ADC and ICI Combinations in TNBC

Establishing the Rationale for ADC and ICI Combinations in TNBC

Virginia Kaklamani, MD, DSc; Tiffany A. Traina, MD, FASCO

Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Breaking Down the Rationale for Targeting TROP2 in TNBC

Breaking Down the Rationale for Targeting TROP2 in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Evaluating the Latest Data and Ongoing Trials for Novel ADC Approaches in TNBC

Evaluating the Latest Data and Ongoing Trials for Novel ADC Approaches in TNBC

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD

Community Oncology Connections™: Monotherapies vs Combinations – Navigating Oral SERDs and Targeted Combination Strategies in HR+/HER2– Metastatic Breast Cancer | Missouri Oncology Society

Community Oncology Connections™: Monotherapies vs Combinations – Navigating Oral SERDs and Targeted Combination Strategies in HR+/HER2– Metastatic Breast Cancer | Missouri Oncology Society

Sara A. Hurvitz, MD, FACP; Shaina Rozell, MD, MPH

Community Oncology Connections™: Monotherapies vs Combinations – Navigating Oral SERDs and Targeted Combination Strategies in HR+/HER2– Metastatic Breast Cancer | Louisiana Oncology Society

Community Oncology Connections™: Monotherapies vs Combinations – Navigating Oral SERDs and Targeted Combination Strategies in HR+/HER2– Metastatic Breast Cancer | Louisiana Oncology Society

Kamel Abou Hussein, MD

Washington State Medical Oncology Society

Washington State Medical Oncology Society

1 Session is Available!

Show Me Your Care Plan!™ Navigating ADC Therapies: Oncology Nursing Strategies for Optimal Patient Management

Show Me Your Care Plan!™ Navigating ADC Therapies: Oncology Nursing Strategies for Optimal Patient Management

August 24, 2026

24th Annual International Congress on the Future of Breast Cancer® East

24th Annual International Congress on the Future of Breast Cancer® East

Joyce O’Shaughnessy, MD

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc; Filipa Lynce, MD; Rita Nanda, MD; Tiffany A. Traina, MD, FASCO

Show Me the Data®: New and Emerging Roles for Oral SERD Therapy in the Treatment of ER+/HER2– Breast Cancer

Show Me the Data®: New and Emerging Roles for Oral SERD Therapy in the Treatment of ER+/HER2– Breast Cancer

Ana C. Garrido-Castro, MD; Pedram Razavi, MD, PhD

Expert Roundtable and Panel Discussions: Current and Future Landscape of TNBC

Expert Roundtable and Panel Discussions: Current and Future Landscape of TNBC

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Tiffany A. Traina, MD, FASCO

Project ECHO®: Advancing Care in Metastatic TNBC Through PD-L1–Informed Novel Frontline ADC Strategies

Project ECHO®: Advancing Care in Metastatic TNBC Through PD-L1–Informed Novel Frontline ADC Strategies

Webinar Series

Arizona Clinical Oncology Society

Arizona Clinical Oncology Society

1 Sessions is Available!

Nevada Oncology Society

Nevada Oncology Society

3 Sessions are Available!

Wisconsin Association of Hematology and Oncology

Wisconsin Association of Hematology and Oncology

2 Sessions are Available!

Tennessee Oncology Practice Society

Tennessee Oncology Practice Society

2 Session are Available!

(CME Track) Antibody–Drug Conjugates in Oncology: The Essentials of AE Management for Better Patient Outcomes

(CME Track) Antibody–Drug Conjugates in Oncology: The Essentials of AE Management for Better Patient Outcomes

Michelle L. Taylor, ANP-BC; Emely Alfaro, DNP, RN, CNS, OCN; Paige Griffith, CRNP; Beth Sandy, MSN, CRNP, FAPO

9th Annual School of Nursing Oncology™

9th Annual School of Nursing Oncology™

Beth Faiman, PhD, MSN, APN-BC, BMTCN, AOCN, FAAN, FAPO; Beth Sandy, MSN, CRNP, FAPO; Lindsay Adkins, MSN, FNP-BC, BMTCN; Jeneth Aquino, DNP, FNP-BC; Casey Gormley, MSN, FNP-C, AOCNP; Heather J. Jackson, PhD, FNP-BC; Kelsey Martin, AG-ACNP-BC, AOCNP; Nerina T. McDonald, PA-C; Lauren Verity Moore, DNP, MSN, AGACNP-BC; Faith A. Mutale, DNP, CRNP; Tiffany Richards, PhD, ANP-BC, AOCNP; Emily Skotte, DNP, MSN, ACNP-BC; Leslie Smith, DNP, RN, APRN-CNS, AOCNS, BMTCN; Saneese Stephen, PA-C, MPAS; Sara M. Tinsley-Vance, PhD, APRN, AOCN

Show Me the Data™: Personalizing First-Line and Maintenance Therapy in HER2+ Metastatic Breast Cancer to Extend Survival and Elevate Quality of Life

Show Me the Data™: Personalizing First-Line and Maintenance Therapy in HER2+ Metastatic Breast Cancer to Extend Survival and Elevate Quality of Life

Sara A. Hurvitz, MD, FACP; Rena Callahan, MD; Michelle Melisko, MD; Paolo Tarantino, MD, PhD

Beyond Primary End Points: Digging Into Randomized and Real-World Data to Guide Challenging Treatment Decisions in HR+/HER2− Metastatic Breast Cancer

Beyond Primary End Points: Digging Into Randomized and Real-World Data to Guide Challenging Treatment Decisions in HR+/HER2− Metastatic Breast Cancer

Seth A. Wander, MD, PhD; Marla D. Lipsyc-Sharf, MD

Medical Crossfire™: Navigating the Expanding Arsenal of Endocrine Therapies for HR+/HER2- Metastatic Breast Cancer – How Can PROTAC ER Degradation Shift the Standard?

Medical Crossfire™: Navigating the Expanding Arsenal of Endocrine Therapies for HR+/HER2- Metastatic Breast Cancer – How Can PROTAC ER Degradation Shift the Standard?

William J. Gradishar, MD, FASCO, FACP; Stephanie L. Graff, MD, FACP, FASCO; Cynthia X. Ma, MD, PhD

Medical Crossfire®: The Who, When, and How of TROP2-Targeting ADCs, ICIs, and PARP inhibition in Triple-Negative Breast Cancer

Medical Crossfire®: The Who, When, and How of TROP2-Targeting ADCs, ICIs, and PARP inhibition in Triple-Negative Breast Cancer

Hope S. Rugo, MD; Alison K. Conlin, MD; Marleen Kok, MD, PhD; Heather McArthur, MD, MPH

Trending on Targeted Oncology - Immunotherapy, Biomarkers, and Cancer Pathways

FDA Accepts NDA for Daraxonrasib in Metastatic Pancreatic Cancer

Advanced Renal Cell Carcinoma: Tailoring Second-Line Therapy After Prior Immunotherapy

Teclistamab/Talquetamab Reduces Risk of Progression by 89% in R/R Multiple Myeloma

Updated HARMONi Analysis Shows Consistent OS Benefit With Ivonescimab in EGFRm Lung Cancer

IMNN-001 Plus Chemo Cuts MRD Rate in Frontline Ovarian Cancer