Yi-Bin Chen, MD, presents an overview of graft versus host disease (GVHD), covering a patient case, first-line and second-line treatment options, associated toxicities, and the potential impact of ongoing clinical trials on the future of GVHD treatment.
EP. 1: Patient Case: Pathology of Graft Versus Host Disease
April 16th 2024Yi-Bin Chen, MD, presents a patient case, detailing the symptomology and pathology of graft versus host disease, such as dry eyes, dry mouth, and difficulty swallowing, while also addressing steroid dependence as an indication for initiating second-line therapy.
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EP. 2: Setting Expectations + First-Line and Second-Line Treatment of Graft Versus Host Disease
April 16th 2024A medical professional outlines the goals and challenges of communicating with his patient, emphasizing the importance of setting realistic expectations for halting disease progression and potentially achieving some degree of disease reversibility, while also exploring the roles of first-line and second-line therapies in the management of chronic graft versus host disease.
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EP. 4: Updates on the iNTEGRATE and ROCKstar Trials
April 23rd 2024Yi-Bin Chen, MD, provides an overview of the iNTEGRATE and ROCKstar trials, underscoring their significance in the current treatment paradigm for graft versus host disease, particularly highlighting their ability to inhibit the fibrosis cascade, which offers substantial benefits for patient healing and recovery.
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EP. 5: Second-Line Medications and Toxicities in GVHD
April 30th 2024A medical expert delves into various aspects of second-line therapies, including dose reductions, potential adverse reactions, and the possibility of transfusions, all of which are important considerations when managing patients on second-line treatments.
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EP. 6: Quality of Life + Clinical Monitoring Outside the Transplant Center
April 30th 2024Yi-Bin Chen, MD, proposes a strategy to enhance patients' quality of life by utilizing virtual monitoring as an alternative to requiring patients to travel to a transplant center, which includes regular remote assessments of blood work, such as liver function tests, lipid panels, and immunoglobulin levels.
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