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Chronic Lymphocytic Leukemia Case Studies

Case Studies: CLL Case Review: IgHV-Unmutated Therapy Options

Matthew S. Davids, MD, MMSc, discussed the data supporting frontline options for newly diagnosed IgHV-unmutated chronic lymphocytic leukemia.

CLL Case Review: IgHV-Unmutated Therapy Options

Case:  A 74-Year-Old Male With IgVH-Unmutated CLL

  • A 74-year-old male presented to PCP with complaints of extreme fatigue, weakness, and weight loss of ~15lbs over the last 3 months.
  • PMH: Mild hypertension managed by statin
  • PE: BP 135/85, enlarged lymph nodes (~6cm), palpable spleen approx. 7cm below costal margin
  • Laboratory findings:
    • WBC; 100 X 109/L
    • Lymphocytes; 82 X 109/L
    • Hb; 15.1 g/dL
    • Platelets; 125 X 109/L
    • ANC; 1,800/mm3
    • LDH 250 u/L
  • β2M, 4.3 mg/L
  • FISH; normal
  • Molecular analysis; IgVH-, TP53 wild-type
  • ECOG PS 1
  • Rai Stage II
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