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Cutaneous Squamous Cell Carcinoma Case Studies

Case Studies: Immunotherapy Potential in Locally Advanced CSCC

Michael R. Migden, MD, shares insight regarding the case of a 69-year-old man who presents with locally advanced cutaneous squamous cell carcinoma and undergoes treatment with cemiplimab.

Immunotherapy Potential in Locally Advanced CSCC

A 69-Year-Old Man With Advanced CSCC

  • History and physical exam
    • An otherwise healthy, 69-year-old male, fair skinned, retired construction worker, widow
    • Presented to his PCP with what he described as a wound that was not healing behind his ear; he reported first noticing it at least 6 months ago and complained of recent onset of numbness in the area.
    • ECOG PS 1
    • The visible, ulcerated lesion was 4.5-cm in diameter and >5-mm deep
    • No palpable nodes
  • Biopsy confirmed a poorly-differentiated, infiltrative, postauricular cutaneous squamous cell carcinoma lesion with 7-mm invasion into subcutaneous fat.
  • The recommended definitive surgical approach involved partial auriculectomy; the patient declined.
  • Cemiplimab 3 mg/kg q2w was initiated
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