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Cutaneous Squamous Cell Carcinoma Case Studies

Case Studies: Recurrent Cutaneous Squamous Cell Carcinoma

Anna C. Pavlick, DO, discusses the case and treatment plan for a 74-year-old man with recurrent cutaneous squamous cell carcinoma.

Recurrent Cutaneous Squamous Cell Carcinoma

Case: A 74-Year-Old Male With Recurrent Metastatic CSCC

November 2017

  • A 74-year-old male from Florida, with history of multiple resections of CSCC on neck, back and shoulders presents with new deep lesion that exhibited perineural invasion and c/o palpable left axillary mass
  • Imaging confirmed 6cm left axillary nodal conglomerate
  • Patient treated with neoadjuvant cisplatin/5FU for 3 cycles
  • Surgical resection of primary lesion; Lymphadenectomy revealed CSCC involvement in 12 out of 16 resected lymph nodes

May 2018

  • Follow-up scans revealed early disease progression with multiple pulmonary nodules
  • Patient started on carboplatin/paclitaxel for 3 cycles

November 2018

  • Repeat imaging showed disease progression in pulmonary nodules and multiple lymphadenopathies; mediastinal, left and right axillary; bone metastases
  • Patient started on cemiplimab for 3 cycles

February 2019

  • Reimaging PET-CT revealed reduction in size and metabolic activity of right and left axillary, and mediastinal lymphadenopathies; pulmonary nodules had considerable reduction in size and were no longer substantial
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