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Gynecologic Cancer Case Studies

Case Studies: A 56-Year-Old Female With Recurrent Ovarian Cancer

An expert discusses the evolving treatment landscape for heavily pretreated recurrent ovarian cancer over the last 4 years, and reviews practice-changing data.

A 56-Year-Old Female With Recurrent Ovarian Cancer

Case:  A 56-Year-Old Female With Recurrent Ovarian Cancer

  • 56-year-old female diagnosed with stage IV ovarian cancer (2016)
    • Weight: 105-lb, height: 5’6”, BMI of 16.9
    • Pathology: high-grade serous carcinoma, epithelial ovarian cancer
    • CA-125: 475 U/mL
    • CT with contrast of the pelvis, abdomen, and chest revealed a 3.5-cm mass in the right ovary and peritoneal carcinomatosis
    • Patient underwent suboptimal debulking surgery; residual disease 1.5 cm
    • Received IV/IP carboplatin/paclitaxel (6 cycles); achieved complete response
  • 1 year later (2017) symptoms returned; CA-125, 265 U/mL; ECOG: 1
    • Received carboplatin/paclitaxel (6 cycles) and bevacizumab; achieved good partial response; CA-125, 45 U/mL; continued on bevacizumab maintenance
  • 8 months following second-line therapy (2018), again presented with symptoms; CA-125, 550 U/mL; ECOG: 0
    • Received carboplatin/gemcitabine (6 cycles); CA-125, 54 U/mL; achieved complete response
  • Currently:
    • CA-125, 585 U/mL
    • CT shows 2.7 cm right lower lobe lung mass
    • ECOG: 0
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