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Myeloproliferative Neoplasms Case Studies

Case Studies: Polycythemia Vera

Ruben A. Mesa, MD, FACP, reacts to the case of a 75-year-old male diagnosed with polycythemia vera and considers treating the patient with a JAK inhibitor based on current trial data.

Polycythemia Vera

Case: 75-Year-Old Man Diagnosed With Polycythemia Vera

January 2018

  • A 75-year old man presents to PCP for routine evaluation; feels well but complains of pruritus exacerbated by hot showers
  • PE: Unremarkable
  • PMH: No prior history of thrombosis, hypertension managed with statin
  • Lab values:
    • HGB:  18.9 g/dL
    • Hct: .56 L/L
    • RBC: 68 x 1012/L
    • WBC:  10.6 x 109/L
    • Serum EPO: 4.1 mU/mL
  • Bone Marrow biopsy declined
  • Cytogenetics: JAK-V617F mutation
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