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Myeloproliferative Neoplasms Case Studies

Case Studies: Underlying Treatment of Myeloproliferative Neoplasms

In this case-based interview, Srdan Verstovsek, MD, provides an overview on the underlying biology and treatment approach for a patient who presents with myelofibrosis.

Underlying Treatment of Myeloproliferative Neoplasms

January 2016

  • A 59-year-old male presents to his physician with symptoms of fatigue and abdominal pain lasting 3 months; he also reports increased bruising
    • Physical Exam: Spleen is palpable, 6 cm. below left costal margin
  • CBC with differential
    • RBC; 3.20 x 1012/L
    • HGB; 9.3 g/dL
    • HCT; 34%
    • MCV; 93.1 fL
    • WBC; 12.1 x 109/L
    • PLT; 247 x 109/L
    • PB BLASTS; 0%
  • Genetic testing shows JAK2 V617F mutation
  • Bone marrow biopsy showed megakaryocyte proliferation and atypia with evidence of reticulin fibrosis
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