January 2014 | Targeted Therapies in Oncology

Genomic Study of Cervical Cancer Identifies Potential Treatment Targets

January 28, 2014

Clinical Articles

Researchers have completed a comprehensive genomic analysis of cervical cancer in two patient populations. The study identified recurrent genetic mutations not previously found in cervical cancer, including one for which targeted agents have been approved in other cancers.

NY-ESO-1 Antigen Spreading With Decitabine Increases Immunotherapy Response

January 23, 2014

Clinical Articles

Treatment with decitabine prior to administration of chemotherapy and a cancer vaccine yielded clinical benefit for women with recurrent ovarian cancer, suggesting that this combinatorial chemoimmunotherapy may provide a new treatment option.

PD-1 and PD-L1 Inhibitors Show Dramatic Response Rates in NSCLC

January 22, 2014

Clinical Articles

The future of PD-1 and PD-L1 inhibition in non-small cell lung cancer (NSCLC) is bright, with ongoing studies suggesting that the strategy will lead to a “new world” in the treatment of the disease.

I-SPY 2 Uses Biomarker Subsets to Evaluate Treatments

January 21, 2014

Clinical Articles

The I-SPY 2 trial, which is evaluating novel agents in the neoadjuvant treatment of breast cancer, may accelerate and influence the way that oncology drugs are tested and approved in the near future.