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Recent Advances in Mantle Cell Lymphoma

Jacqueline D. Barrientos, MD, MS
Published Online:4:56 PM, Thu September 6, 2018

Jacqueline D. Barrientos, MD, MS, associate professor, The Feinstein Institute for Medical Research, Northwell Health, discusses the most recent advances in mantle cell lymphoma (MCL), as well as the challenges investigators still face in the field.

Acalabrutinib (Calquence), a second-generation Bruton's tyrosine kinase inhibitor, was approved by the FDA last year for the treatment of patients with mantle cell lymphoma following at least 1 prior therapy. This drug works similarly to ibrutinib (Imbruvica) in this patient population.

While this an exciting advancement in the field, Barrientos says that patients with MCL still have the issue of relapse. Researchers are currently looking for combination strategies that can achieve longer remission or progression-free survival in patients.

A number of new agents and advancements are being investigated in MCL right now, but unfortunately, there are still limited therapies for these patients, Barrientos says.
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