Cathy Eng, MD, FACP, FASCO, reviews the case of a 68-year-old diagnosed with metastatic NTRK fusion-positive colon cancer and shares treatments options.
Case: A 68-Year-Old Woman With Metastatic NTRK Fusion-Positive Colon Cancer
Initial presentation
A 68-year-old woman presented with a 3-month history of intermittent abdominal pain, and alternating constipation/diarrhea
PMH/SH: hypertension and hypercholesterolemia, medically managed; colonoscopy at age 50 was unremarkable; never smoker; no family history of cancer
PE: abdomen tender on deep palpation in the right lower quadrant
Clinical workup
Labs: Hb 11.9, Hct 32%, MCV 75 fL, CEA 12.8 ng/mL
Chest/abdominal/pelvic CT showed a 5-cm right sided bowl mass and multiple hepatic lesions, and regional lymphadenopathy
Colonoscopy revealed a 5-cm mass in the ascending colon, biopsy was taken
Pathology: grade 3 poorly differentiated adenocarcinoma, with invasion of the submucosa