Nathan Pennell, MD, PhD, discusses the cost-effectiveness of adjuvant osimertinib in resected EGFR-mutant non-small cell lung cancer.
Nathan Pennell, MD, PhD, a medical oncologist at the Cleveland Clinic, discusses the cost-effectiveness of adjuvant osimertinib (Tagrisso) in resected EGFR-mutant non-small cell lung cancer (NSCLC).
According to Pennell, at a 5% improvement in survival, osimertinib has a cost effectiveness ratio of $317,000, much higher than the commonly drug cost of $195,000 in the United States. This means, at the current cost, adjuvant osimertinib does not appear to be cost effective in this patient population.
However, the hope is that osimertinib turns out to be much more effective than previously reported, according to Pennell. If the effectiveness rate is between 25% to 30%, the agent would prove to be cost effective at the current standard. Additionally, if osimertinib was half the price, the drug would be cost-effective at 5%.
FDA Grants Breakthrough Therapy Designation to Sunvozertinib in EGFR Exon20+ NSCLC
April 9th 2024Sunvozertinib was granted breakthrough therapy designation by the FDA for the first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer harboring an EGFR exon 20 insertion mutation.
Read More
Amivantamab/Lazertinib Still Effective in EGFRm NSCLC Despite Dose Interruptions
March 26th 2024According to a subset analysis of the phase 3 MARIPOSA trial, dose interruptions during the course of amivantamab and lazertinib treatment were still effective in EGFR-mutant non-small cell lung cancer.
Read More