Charles Fuchs, MD: RAS Mutations in Metastatic Colorectal Cancer
About what percent of patients with metastatic CRC harbor RAS mutations?
As I say now with extended RAS testing, whereas we used to think maybe 35% of patients harbor a RAS mutation when we did just EXON 2 KRAS mutations, we now know that when you extend to all KRAS mutations and all NRAS mutations, 50% of patients harbor a mutation. In fact, one of the most recent analyses showed that 52% of patients have a RAS mutation, such that perhaps even more than half are patients who harbor that mutation for whom you don't want to give that antibody.
Unresectable Colon Cancer: Case 2
52-year-old woman newly diagnosed with metastatic CRC and is genotyped as part of her initial work up.
Retrospective Data Demonstrates Efficacy of Regorafenib in mCRC
April 16th 2024During a Case-Based Roundtable® event, Madappa Kundranda, MD, PhD, discussed recent retrospective studies that compared outcomes between the available treatment options in patients with relapsed/refractory advanced colorectal cancer in the first article of a 2-part series.
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Peritoneal RFS May Be a Stronger Predictor of OS in CRC Peritoneal Metastasis
March 27th 2024In an interview with Targeted Oncology, Muhammad Talha Waheed, MBBS, discussed research on the reliability of using recurrence-free survival as an efficacy end point for trials evaluating patients with colorectal cancer peritoneal metastasis.
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Study Finds Susceptibility Gene Variations by Race/Ethnicity in Early-Onset CRC
February 20th 2024In an interview with Targeted Oncology, Andreana N. Holowatyj, PhD, MSCI, discussed data from a study which found racial and ethnic differences in susceptibility genes for early-onset colorectal cancer, suggesting current multigene panel tests may not be accurate for diverse populations.
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