About what percent of patients with metastatic CRC harbor RAS mutations?
As I say now with extended RAS testing, whereas we used to think maybe 35% of patients harbor a RAS mutation when we did just EXON 2 KRAS mutations, we now know that when you extend to all KRAS mutations and all NRAS mutations, 50% of patients harbor a mutation. In fact, one of the most recent analyses showed that 52% of patients have a RAS mutation, such that perhaps even more than half are patients who harbor that mutation for whom you don't want to give that antibody.
Unresectable Colon Cancer: Case 2
52-year-old woman newly diagnosed with metastatic CRC and is genotyped as part of her initial work up.
The Impact of the Gut Microbiome in Young Patients With Colorectal Cancer
February 15th 2021In season 2, episode 2 of Targeted Talks, Cathy Eng, MD, speaks with Benjamin Weinberg, MD, about the gut microbiome, and how the presence of certain microbiota impact the onset and intensity of disease as well as the potential response to certain treatments.
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The Expanding Role of the Gut Microbiome in CRC
February 24th 2023Encouraging results in melanoma have led experts to explore the gut microbiome in colorectal cancer. The next hot topic in research may be the gut microbiome's role for the prevention, progression, and management of colorectal cancer.
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