Daratumumab as a Potential Treatment Option for Multiple Myeloma
Jacob Laubach, MD, MPP, from Dana-Farber Cancer Institute and an Instructor in Medicine at the Harvard Medical School, discusses daratumumab as a potential treatment option for patients with multiple myeloma.
Jacob Laubach, MD, MPP, from Dana-Farber Cancer Institute and an Instructor in Medicine at the Harvard Medical School, discusses daratumumab as a potential treatment option for patients with multiple myeloma.
Clinical Pearls:
- Daratumumab is a first-in-class CD38 monoclonal antibody
- Since CD38 is present on a number of other cell types, the first in-human dose-finding study proceeded cautiously with 0.005 mg/kg of the agent with dose escalation to 24 mg/kg
- At doses of 4 mg/kg or higher, the overall response rate, including minimal response, was over 60% and the rate of partial response or better was in the range of 40% to 45%, as defined as a 50% reduction in monoclonal protein
- Daratumumab was well tolerated but some infusion reactions were observed, specifically early on in the trial
- Daratumumab is now being studied in combination with other drugs, such as lenalidomide
Age, Disease Burden Are Factors in Early Use of Selinexor in Multiple Myeloma
April 22nd 2024During a Case-Based Roundtable® event, Jonathan L. Kaufman, MD, discussed treatment approaches and the tolerability of a selinexor-containing regimen in a patient with relapsed/refractory multiple myeloma in the first article of a 2-part series.
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