Expert Discusses Data for FLYER Trial in Patients With DLBCL

December 19, 2018
Viola Poeschel, MD

Viola Poeschel, MD, discusses the results for the phase III FLYER trial in which the standard 6 cycles of R-CHOP were compared to a reduced 4 cycles of R-CHOP in patients with diffuse large B-cell lymphoma

Viola Poeschel, MD, a medical doctor at the Saarland University Medical School, discusses the results for the phase III FLYER trial in which the standard 6 cycles of R-CHOP were compared to a reduced 4 cycles of R-CHOP in patients with diffuse large B-cell lymphoma (DLBCL).

At 3-year follow-up, the standard regimen has a 94% progression-free survival rate compared to 96% with the reduced treatment with 4 cycles, Poeschel says. These data show the newer regimen is noninferior to the standard of care.

In regard to efficacy, both arms had similar event-free survival and no difference in overall survival, Poeschel adds. The 4 cycles of R-CHOP also reduced toxicity, where the 6-cycle regimen led to a higher hematologic toxicity profile. Poeschel notes that the total number of non-hematologic toxicities could be reduced by using only 4 cycles compared to the standard 6 cycles of R-CHOP.