Phase I/II Study Demonstrates Good Efficacy for Gastric Cancer

Commentary
Video

Shuichi Hironaka, MD, PhD, discusses the efficacy of a phase I/II study of nivolumab, paclitaxel, and ramucirumab as second-line treatment of patients with advanced gastric cancer during the 2020 Gastrointestinal Cancers Symposium.

Shuichi Hironaka, MD, PhD, a medical oncologist at the Chiba Cancer Center in Japan, discusses the efficacy of a phase I/II study (UMIN000025947) of nivolumab (Opdivo), paclitaxel (Taxol), and ramucirumab (Cyramza) as second-line treatment of patients with advanced gastric cancer during the 2020 Gastrointestinal Cancers Symposium.

The overall response rate for patients in this study was about 37%, and the 6-month progression-free survival (PFS), which was a primary endpoint of the study, was about 46%, according to Hironaka. The median PFS and overall survival were about 5 months and about 13 months, respectively. There were 43 patients enrolled, and the median follow-up time was almost 7 months. The 18-month survival rate was about 32%.

Hironaka believes these efficacy results are promising compared to prior data such as RAINBOW, a phase III trial of ramucirumab and paclitaxel versus placebo and paclitaxel in patients with previously treated advanced gastric or gastro-esophageal junction adenocarcinoma. He says that this regimen showed promising data for patients in this setting.

<< View more from the 2020 Gastrointestinal Cancers Symposium

Related Videos
David Zhen, MD, an expert on gastric cancer
David Zhen, MD, an expert on gastric cancer
David Zhen, MD, an expert on gastric cancer
David Zhen, MD, an expert on gastric cancer
David Zhen, MD, an expert on gastric cancer
David Zhen, MD, an expert on gastric cancer
David Zhen, MD, an expert on gastric cancer
Related Content