EGFR+ NSCLC

December 2017

• A 66-year-old Asian woman presents to her PCP complaining of visual disturbances, nausea, fatigue, and sporadic headaches
• History: HTN, managed on candesartan; hyperlipidemia managed on simvastatin; no smoking history
• PE: BP, 148/70; LLL auscultation reveals decreased breath sounds
• CBC: WNL
• Imaging studies:
  • MRI of the head demonstrated a right parietal mass at the gray—white junction with vasogenic edema
  • CT of chest, abdomen, and pelvis revealed a 3.4-cm mass in the left lower lobe, and several small liver nodules
• CT-guided transthoracic needle biopsy of the lung lesion showed grade 2 adenocarcinoma, acinar
• Molecular testing: EGFR exon 19 deletion
• Staging: T2aN0M1c
• ECOG 1
• The patient was started on osimertinib 80 mg once daily