What are some issues that impede widespread adoption of recommended testing for RAS mutations?
A lot of the factors relate to presence of tissue, availability of tissue, presence of adequate tissue, so tissue might be available but it's not adequate enough to allow testing. Logistical, and that's very important. Let's say a patient comes into a clinic at the university and has had their biopsy at their community hospital. By the time they see the oncologist and there's a treatment plan to be decided, the tissue is in a different place. By the time you get the tissue and you get it tested, that's 6 weeks. So logistically it's very challenging and the patients will not wait 4 to 6 weeks before they start their treatment, especially since there's no data that suggests that an EGFR inhibitor is superior to a VEGF inhibitor.
Unresectable Colon Cancer: Case 2
52-year-old woman newly diagnosed with metastatic CRC and is genotyped as part of her initial work up.
Retrospective Data Demonstrates Efficacy of Regorafenib in mCRC
April 16th 2024During a Case-Based Roundtable® event, Madappa Kundranda, MD, PhD, discussed recent retrospective studies that compared outcomes between the available treatment options in patients with relapsed/refractory advanced colorectal cancer in the first article of a 2-part series.
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Peritoneal RFS May Be a Stronger Predictor of OS in CRC Peritoneal Metastasis
March 27th 2024In an interview with Targeted Oncology, Muhammad Talha Waheed, MBBS, discussed research on the reliability of using recurrence-free survival as an efficacy end point for trials evaluating patients with colorectal cancer peritoneal metastasis.
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Study Finds Susceptibility Gene Variations by Race/Ethnicity in Early-Onset CRC
February 20th 2024In an interview with Targeted Oncology, Andreana N. Holowatyj, PhD, MSCI, discussed data from a study which found racial and ethnic differences in susceptibility genes for early-onset colorectal cancer, suggesting current multigene panel tests may not be accurate for diverse populations.
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