Trial Designs in Ovarian Cancer

Clinical Pearls

Jason D. Wright, MD, Division Chief, Gynecologic Oncology, Associate Clinical Professor of Gynecologic Oncology, Sol Goldman Associate Professor of Obstetrics and Gynecology, Columbia University, discusses clinical trial designs in ovarian cancer.

• Many patients with ovarian cancer receive a variety of off-label therapies. Nevertheless, overall survival has improved.
• The ovarian cancer community must weigh the pros and cons of a sound trial design with its application in the real world.
• Progression-free survival has its limitations but is probably the most reasonable trial endpoint.