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GI CANCERSGI CANCERSGI CANCERSGI CANCERSGI CANCERS
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Christin L. Melton, ELS

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Recent Studies Point to a Greater Role for PARP Inhibitors in Solid Tumors

Recent Studies Point to a Greater Role for PARP Inhibitors in Solid Tumors

November 19th 2019

The early development of PARP inhibitors in 2003 focused on their use in combination with cytotoxic chemotherapy agents, but this was eventually abandoned because of excess toxicity.


Melanoma Investigators Strive to Overcome PD-1 Inhibitor Resistance

Melanoma Investigators Strive to Overcome PD-1 Inhibitor Resistance

May 17th 2019

Investigators across the globe have expended considerable effort attempting to identify mechanisms of response and resistance to ICIs. The general conclusion is that each patient’s response to immunotherapy is likely complex and highly individualized.


A Little STING May Enhance the Immune System Against Cancer

A Little STING May Enhance the Immune System Against Cancer

April 25th 2015

Despite their promise, checkpoint inhibitors are not effective in every patient, and research suggests the STING (stimulator of interferon genes) pathway may hold important clues as to why some tumors fail to respond.

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