Sylvia Adams, MD

Sylvia Adams, MD, associate professor, Department of Medicine, director, Clinical Research, Breast Cancer Disease Management Group, NYU Langone Medical Center, discusses the synergy between anti-CTLA4 and anti-PD-L1 antibodies as treatment of patients with breast cancer.

Adams says this is a powerful combination. The anti-CTLA4 agent helps to unleash the immune response and invigorates the response, while anti-PD-L1 agents can further stimulate the T cell response. Overall, these are powerful immunotherapeutics, Adams says, and have demonstrated their ability in other cancers, such as melanoma.

In breast cancer, anti-PD-L1 therapy has already been approved for the treatment of patients with triple-negative breast cancer, but there is no approval for routine use of this therapy in breast cancer. These agents also tend to carry some toxicity, so Adams says she tries to limit use of this therapy to patients in trials that have poor prognosis.

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Sylvia Adams, MD, discusses the synergy between anti-CTLA4 and anti-PD-L1 antibodies as treatment of patients with breast cancer.

Combination Immunotherapy Appears Promising in Breast Cancer Subtypes

Sylvia Adams, MD, associate professor, Department of Medicine, NYU Langone Medical Center, discusses phase II results from cohort A of the KEYNOTE-086 trial, which explored pembrolizumab monotherapy for previously treated metastatic triple-negative breast cancer.

Phase II Results for Pembrolizumab Monotherapy in Metastatic TNBC

Sylvia Adams, MD, medical oncologist, NYU Langone Medical Center, talks about the the importance of tumor-infiltrating lymphocytes (TILS) and how they can mark which patients will respond to immunotherapy use in triple negative breast cancer (TNBC). She discussed this topic at the recent Chemotherapy Foundation Symposium.

She says that according to a study on 500 patients, these lymphocytes predict response to treatment in TNBC patients. She adds that the same results were seen in other investigators around the globe. This information is important to medical oncologists because it shows what types of breast cancers will potentially respond to immunotherapies.

Sylvia Adams, MD, medical oncologist, NYU Langone Medical Center, talks about the the importance of tumor-infiltrating lymphocytes (TILS) and how they can mark which patients will respond to immunotherapy use in triple negative breast cancer (TNBC). She discussed this topic at the recent Chemotherapy Foundation Symposium. 


Sylvia Adams, MD | Authors

Articles

Combination Immunotherapy Appears Promising in Breast Cancer Subtypes

Phase II Results for Pembrolizumab Monotherapy in Metastatic TNBC

Dr. Sylvia Adams on Tumor-Infiltrating Lymphocytes in Triple Negative Breast Cancer