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Expert Highlights the Clinical Utility of RNA Sequencing Methods in Cancer

Kevin Halling, MD, PhD
Published Online: 8:38 PM, Fri November 8, 2019

Kevin Halling, MD, PhD, a consultant in the Division of Laboratory Genetics and Genomics and Department of Laboratory Medicine and Pathology at the Mayo Clinic, discussed the clinical utility of RNA-sequencing methods in patients with cancer at the 2019 Association for Molecular Pathology (AMP) Annual Meeting and Expo. Halling says RNA sequencing is a very powerful diagnostic technique.

According to Halling, these methods can be used to detect not only gene fusions in patients with cancer, but RNA sequencing can also detect point mutations and small indels. Additionally, pathologists can use RNA sequencing techniques to measure gene expression in the patient’s tumors.

The role of RNA sequencing is evolving in many laboratories as a tool for detecting gene fusions, but the clinical utility will continue to expand, Halling concludes. RNA sequencing is important because so much information can be gained from 1 test. This provides a lot of value for the money spent on a single test.

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