Phase II Results of the GEOMETRY Mono-1 Study in NSCLC
Juergen Wolf, MD, medical director, Center for Integrated Oncology (CIO) at the University Hospital Cologne, discusses the phase II findings of the GEOMETRY mono-1 study in patients with MET exon 14-mutated advanced non-small cell lung cancer.
Juergen Wolf, MD, medical director, Center for Integrated Oncology (CIO) at the University Hospital Cologne, discusses the phase II findings of the GEOMETRY mono-1 study in patients withMETexon 14-mutated advanced non-small cell lung cancer (NSCLC).
In findings from the GEOMETRY trial presented at the 2018 ESMO Congress, an overall response rate (ORR) of 72.0% was observed for the investigational MET inhibitor capmatinib (INC280) in treatment-naive patients and 39.1% in previously treated patients. The safety profile was tolerable, and results suggest that this agent may be beneficial to patients with exon 14 skipping mutations.
These first-line data are very exciting, Wolf says, as this ORR has never been reported in patients withMET
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