A key opinion leader reviews the case of a 71-year-old woman with NTRK gene fusion thyroid cancer and considers novel therapies available for the management of her disease.
Case: A 71-Year-Old Woman With Thyroid NTRK Gene Fusion Cancer
Initial Presentation
A 71-year-old woman presents with a painless “ball on his neck”
Ultrasound of the neck revealed a 3.8 cm suspicious mass arising from the left thyroid; 4 suspicious submandibular lymph nodes, largest 2.2 cm in size
Ultrasound-guided FNAB of the thyroid mass and the largest lymph node confirmed undifferentiated papillary thyroid carcinoma
Chest/abdominal/pelvic CT showed no evidence of distant metastases
Patient underwent total thyroidectomy with therapeutic central compartment and left selective neck dissection
Pathology: 3.8 cm undifferentiated papillary thyroid cancer arising in left lobe of thyroid, 2 of 7 positive central compartment lymph nodes, largest 1.3 cm, no extra nodal extension
StageT2N1M1; ECOG PS 0
Follow-Up and Additional Treatment
She was treated with radioactive iodine 150 millicuries
Whole body scan showed uptake in neck only consistent with thyroid remnant
Added levothyroxine to regimen
Follow-up at 2 months TSH 0.2 mU/L; thyroglobulin 26 ng/mL