In separate, live virtual events, Kami J. Maddocks, MD, and Sairah Ahmed, MD, discussed the use of loncastuximab tesirine for a patient with later-line diffuse large B-cell lymphoma.
CASE SUMMARY
EVENT REGION Kentucky, Michigan, Illinois, Indiana, Ohio, and Wisconsin
KAMI J. MADDOCKS, MD: Do you agree with this treatment choice? Who has heard of or used loncastuximab?
MOHAMAD K. KHASAWNEH, MD: This is a scenario that I would seriously consider loncastuximab for because the patient seems to know that treatment is palliative at this time. She’s not looking into any intensive treatment with the hope of cure. She has a difficult social situation of taking care of her mom. I have used single-agent loncastuximab [before], and it’s definitely a great option at this time because of its mechanism of action. It does have its own adverse event [AE] profile, like fluid overload, fatigue, and some myelosuppression, [although] not as high as we see with chemotherapy or tafasitamab-cxix [Monjuvi] and lenalidomide [Revlimid].
NEERAJ MAHAJAN, MD: I have used loncastuximab and it turned out to be the most practical and logistically feasible single agent, given every 3 weeks, 30 to 45 minutes infusion, with no premedications, so you don’t have to combine it with BR and you don’t have to get [patients] approved for lenalidomide. AEs are there, but compared with other options, I think they are still manageable. At least for a lot of these patients who have these issues with travel and comorbidities, that is a reasonable choice; at least in the community setting and from the scheduling and doing the infusions for those patients, it is the most convenient of [the treatment options].
MARK H. KNAPP, MD: I’ve also used it. It seems very convenient for the patient every 3 weeks—a short infusion. The patient I had tolerated it, is on it currently, and tolerated it much better than their second-line therapy.